Prenatal stress produces more behavioral alterations than maternal separation in the elevated plus-maze and in the elevated T-maze
Prenatal stress produces more behavioral alterations than maternal separation in the elevated plus-maze and in the elevated T-maze
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DOI：
10.1016/j.bbr.2005.04.003
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发表时间：
2005-08-20
影响因子：
2.7
通讯作者：
Morato, S
中科院分区：
文献类型：
--
作者：
Estanislau, C;Morato, S
产前压力和母亲分离被用于大量的研究早期逆境的后果，并提出了一些相似之处，他们的影响。本工作调查的行为影响，这两个程序上的两个模型的焦虑：高架十字迷宫和高架T-迷宫。在怀孕期间，雌性大鼠每隔一天接受一次无法控制的足部电击，或保持不受干扰。分娩后，从未受干扰的母鼠窝提交给从出生后第3- 14天每天180分钟的母体分离期或保持与母鼠的所有时间。从出生后第3- 14天开始，应激母鼠的窝仔不受干扰。仅对男性进行了检测。成年后，在高架T迷宫或高架十字迷宫中测试大鼠。在后一个程序中，一半的受试者在测试前立即接受60分钟的约束。在高架十字迷宫中采取以下措施：进入手臂、伸展、直立、梳理和头部浸入的频率和时间。在T-迷宫中，使用回避和逃避迷宫措施。我们的数据表明，产前压力有更明显的焦虑的影响比母亲的分离，判断减少探索的高架十字迷宫的开放臂，但主要是在约束压力，并增加回避laveling高架T-迷宫。不直接参与高架十字迷宫臂探索的其他测量结果相似。我们的数据表明，产前压力导致更多的焦虑的影响，在成年期比母亲分离，但在高架十字迷宫，这些焦虑的影响是更好地看到后立即急性压力。(C)2005 Elsevier B. V.保留所有权利。
Prenatal stress and maternal separation are used in a large number of studies on early adversity consequences and present some similarities in their effects. The present work investigates the behavioral effects of these two procedures on two models of anxiety: the elevated plus-maze and the elevated T-maze. During pregnancy, female rats were submitted to uncontrollable electric foot shock sessions every other day or kept undisturbed. After delivery, litters from undisturbed dams were submitted to either 180-min daily periods of maternal separations from the 3-14th postnatal days or maintained with the dams all the time. Litters from the stressed dams were left undisturbed from the 3-14th postnatal days. Only males were tested. In adulthood, rats were tested in the elevated T-maze or in the elevated plus-maze. In the latter procedure half the subjects were submitted to a 60-min period of restraint immediately before being tested. The following measures were taken in the elevated plus-maze: frequency and time spent in entries into the arms, stretching, rearing, grooming and head dipping. In the T-maze measures of avoidance and escape latencies were used. Our data indicated that prenatal stress had more pronounced anxiogenic effects than maternal separation, as judged by reduced exploration of the open arms of the elevated plus-maze, but mainly after the restraint stress, and increase in avoidance latencies in the elevated T-maze. The other measures not directly involved in the elevated plus-maze arm exploration yielded similar results. Our data indicate that prenatal stress causes more anxiogenic effects in adulthood than maternal separation but, in the elevated plus-maze, these anxiogenic effects are better seen immediately after an acute stress. (C) 2005 Elsevier B.V. All rights reserved.