Molecular interactions in pulmonary surfactant films
Molecular interactions in pulmonary surfactant films
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DOI：
10.1159/000056765
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Pérez-Gil, J
中科院分区：
文献类型：
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作者：
Pérez-Gil, J
肺表面活性物质是一种脂质-蛋白质复合物，具有稳定肺呼吸表面以防止萎陷的重要生理作用。为了实现这一功能，表面活性剂在空气-液体界面处形成膜，该膜显著降低了衬在肺泡上的薄水层的表面张力。天然表面活性剂优化了两个重要特性。一旦分泌到肺泡腔，表面活性剂迅速吸附到界面。在那里，当在呼气期间压缩时，表面活性剂膜将表面张力降低至接近OmN/m。用于呼吸治疗的有效人工表面活性剂的设计和生产关键取决于在呼吸循环的背景下管理有效界面吸附和最佳表面活性的分子机制的知识。本综述总结了现有的数据，肺表面活性物质的不同分子组分在气液界面的行为。一个工作模型，提出了如何表面活性剂薄膜可以调节呼吸动力学。版权所有（C）2002 S. Karger AG，巴塞尔。
Pulmonary surfactant is a lipid-protein complex which has the essential physiological role of stabilizing the respiratory surface of lungs against collapse. To achieve this function, surfactant forms films at the air-liquid interface that reduce dramatically the surface tension of the thin aqueous layer lining the alveoli. Natural surfactant has optimised two important properties. Once secreted to the alveolar spaces, surfactant adsorbs rapidly to the interface. There, surfactant films reduce surface tension close to 0 mN/m when compressed during expiration. The design and production of efficient artificial surfactants for respiratory therapeutics is critically dependent on the knowledge of the molecular mechanisms governing efficient interfacial adsorption and optimal surface activity, in the context of respiratory cycling. The present review summarizes the data available today on the behaviour of the different molecular components of pulmonary surfactant at air-liquid interfaces. A working model is proposed of how surfactant films could modulate the respiratory dynamics. Copyright (C) 2002 S. Karger AG, Basel.