Deceased donors with a past history of malignancy: An Organ Procurement and Transplantation Network/United Network for Organ Sharing update
Deceased donors with a past history of malignancy: An Organ Procurement and Transplantation Network/United Network for Organ Sharing update
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DOI：
10.1097/01.tp.0000267919.93425.fb
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发表时间：
2007-07-27
期刊：
影响因子：
6.2
通讯作者：
Hanto, Douglas W.
中科院分区：
文献类型：
--
作者：
Kauffman, H. Myron;Cherikh, Wida S.;Hanto, Douglas W.
大约2%的死者器官移植来自有癌症病史的捐赠者。器官获取和移植网络/器官共享联合网络对2000年至2005年39,455名已故捐赠者的数据进行了分析，结果显示，1069名捐赠者患有PHC，导致2508例移植，包括1236例肾脏，891例肝脏，199例心脏，100例肺和82例其他器官。供体中最常见的既往癌症类型是非黑色素瘤皮肤癌（n=776），其次是中枢神经系统恶性肿瘤（n=642）和宫颈癌（n=336）。一名患有多形性胶质母细胞瘤的捐赠者将致命的肿瘤转移给了三名接受者。一名32年前有黑色素瘤病史的供体将致命的黑色素瘤传播给一名受体，因此，不应使用有黑色素瘤病史的供体。有癌症病史的捐献者如果有非创伤性脑出血，会引起关注，因为这种出血可能是未被识别的转移性肿瘤的结果。
Approximately 2% of deceased donor organ transplants result from donors with a past history of cancer. An analysis of Organ Procurement and Transplantation Network/United Network for Organ Sharing data on 39,455 deceased donors from 2000 to 2005 showed 1069 donors had a PHC, resulting in 2508 transplants, including 1236 kidneys, 891 livers, 199 hearts, 100 lungs, and 82 miscellaneous organs. The most common type of previous cancer in the donor was nonmelanoma skin cancer (n=776) followed by central nervous system malignancies (n=642) and carcinoma of the uterine cervix (n=336). One donor with a glioblastoma multiforme transmitted fatal tumors to three recipients. One donor with a history of melanoma 32 years earlier transmitted a fatal melanoma to a single recipient and, therefore, donors with a history of melanoma should not be used. Donors with a past history of cancer who have a nontraumatic cerebral hemorrhage cause concern because this hemorrhage may be the result of an unrecognized metastatic tumor.