Neural correlates of citalopram and placebo response in acute bipolar depression: A randomized trial.
Neural correlates of citalopram and placebo response in acute bipolar depression: A randomized trial.
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DOI：
10.1016/j.jpsychires.2021.04.035
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发表时间：
2021-06
影响因子：
4.8
通讯作者：
Ghaemi SN
中科院分区：
文献类型：
--
作者：
Sretavan Wong K;Migó M;Dougherty DD;Ghaemi SN
虽然5-羟色胺再摄取抑制剂有时在临床实践中用于治疗急性双相抑郁症，但对其疗效的神经生理学基础研究甚少。在一个更大的临床疗效试验的背景下，本研究探讨了西酞普兰与安慰剂治疗双相抑郁症相关的神经机制。FDG-PET成像检查治疗前后全脑代谢的变化。西酞普兰与安慰剂的临床疗效相似。神经影像学结果显示，治疗前（西酞普兰和安慰剂联合受试者）左眶额皮质（OFC）的葡萄糖代谢高于治疗后，但与临床恢复无关。当基线扫描与基线MADRS评分回归时，左眶额皮层葡萄糖代谢也是抑郁严重程度的预测因子。尽管我们的样本量小，可能动力不足的全脑分析方法，这些初步结果表明，OFC，一个关键区域参与奖励回路，可能是一个神经基板的抑郁症状改善双相抑郁症，无论是由于积极治疗或安慰剂。
While serotonin reuptake inhibitors are sometimes used in clinical practice to treat acute bipolar depression, the neurophysiological substrates underlying their efficacy are little studied. In the context of a larger clinical efficacy trial, the present study explored neural mechanisms associated with citalopram versus placebo treatment for bipolar depression. FDG-PET imaging examined whole-brain metabolic changes before and after treatment. Clinical efficacy was similar for citalopram versus placebo. Neuroimaging results demonstrated greater glucose metabolism in the left orbitofrontal cortex (OFC) before treatment (combined citalopram and placebo subjects) relative to after treatment, but did not correlate with clinical recovery. Glucose metabolism in the left OFC was also a predictor of depression severity when baseline scans were regressed with baseline MADRS scores. Despite of our small sample size and possibly underpowered whole-brain analysis approach, these preliminary results suggest the OFC, a key region involved in reward circuity, may be a neural substrate for depressive symptom improvement in bipolar depression, regardless of whether due to active treatment or placebo.
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影响因子：
4.1
作者：
Nusslock R;Young CB;Damme KS
通讯作者：
Damme KS
影响因子：
5.7
作者：
Macoveanu, Julian;Fisher, Patrick M.;Siebner, Hartwig R.
通讯作者：
Siebner, Hartwig R.
影响因子：
17.7
作者：
Mayberg, HS;Silva, JA;Jerabek, PA
通讯作者：
Jerabek, PA
影响因子：
5.3
作者：
Ghaemi, S. Nassir;Whitham, Elizabeth A.;Patkar, Ashwin A.
通讯作者：
Patkar, Ashwin A.
DOI：
10.1196/annals.1401.029
发表时间：
2007-01-01
期刊：
LINKING AFFECT TO ACTION: CRITICAL CONTRIBUTIONS OF THE ORBITOFRONTAL CORTEX
影响因子：
--
作者：
Drevets, Wayne C.
通讯作者：
Drevets, Wayne C.