The carbon dioxide and oxygen content of the blood after ligation of the abdominal aorta and the inferior vena cava
The carbon dioxide and oxygen content of the blood after ligation of the abdominal aorta and the inferior vena cava
复制标题
腹主动脉和下腔静脉结扎后血液中二氧化碳和氧气的含量
DOI：
10.3181/00379727-10-109
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发表时间：
1913
影响因子：
--
通讯作者：
R. Giles
中科院分区：
文献类型：
--
作者：
J. Murlin;L. Edelmann;R. Giles
在结扎腹主动脉和下腔静脉1后对正常和去胰麻醉动物进行的呼吸实验，以及在通过将门静脉连接到下腔静脉2而排除肝脏后对正常动物进行的呼吸实验显示呼吸商增加，Noorden学派解释为证明了去胰腺动物体内糖的燃烧和正常动物的依赖性肝脏燃烧蛋白质和脂肪的能力。然而，这些实验并没有伴随着血气分析。循环气流缩短后呼吸商较高，可能是由于氧气吸收受到干扰（肺被动充血），或由于血液通过肺更快速循环而增加了二氧化碳的消除。初步的一些呼吸实验中，我们正在寻找解释呼吸商的改变，我们已经做了一些实验，正常狗分析颈动脉血之前和之后，同时夹紧腹主动脉和下腔静脉。结果如下：使用氯酮麻醉。在最后一只狗的情况下，它消除了大约80个C. C。如果每分钟减少57%到34%的二氧化碳，那么在一小时的时间里，人体将排出约800 C. C.。二氧化碳或足以提高R. Q.从0.75到0.88。我们不能像波热斯那样假设，在这种情况下，血气会在10-15分钟内达到平衡，因为当血液循环减少到一半，心脏以正常或更高的速度跳动时，血液会以两倍的频率通过肺部，并继续损失二氧化碳，直到所有组织的张力都大大降低。
Respiration experiments on normal and depancreatized anaesthetized animals after ligation of the abdominal aorta and the inferior vena cava 1 and on normal animals after exclusion of the liver by joining the portal vein to the inferior vena cava 2 show an increase in the respiratory quotient, which is interpreted by the v. Noorden school to demonstrate the combustion of sugar in the depancreatized animal and the dependence of the normal animal upon the liver for its ability to burn protein and fat. These experiments, however, were not accompanied by analyses of the blood gases. It is possible that the higher respiratory quotient after shortening of the circulating stream might be due to an interference with the oxygen absorption (passive congestion of the lungs) or to increased elimination of carbon dioxide by more rapid circulation of the blood through the lungs. Preliminary to some respiration experiments on depancreatized dogs in which we are seeking the explanation of the altered respiratory quotient, we have made a number of experiments on normal dogs analyzing the carotid blood before and after simultaneous clamping of the abdominal aorta and the inferior vena cava. The results follow: Chloretone anaesthesia was used. In the case of the last dog which eliminated about 80 C.C. of CO2 per minute, it may be estimated that a reduction from 57 to 34 per cent. would remove from the body in the course of one hour, about 800 C.C. of CO2 or enough to raise the R. Q. from 0.75 to 0.88. It cannot be assumed as Porges has done that the blood gases, under the circumstances, would reach an equilibrium within 10-15 minutes, for with the circulation diminished to one half and the heart beating at its normal rate, or higher, the blood would pour through the lungs twice as often and would continue to lose carbon dioxide until the tension in all the tissues became very much reduced.