From Genes to Transcripts, a Tightly Regulated Journey in Plasmodium.
From Genes to Transcripts, a Tightly Regulated Journey in Plasmodium.
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从基因到转录本，疟原虫的严格监管之旅。
DOI：
10.3389/fcimb.2020.618454
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发表时间：
2020
影响因子：
5.7
通讯作者：
Le Roch KG
中科院分区：
文献类型：
--
作者：
Hollin T;Le Roch KG
Over the past decade, we have witnessed significant progresses in understanding gene regulation in Apicomplexa including the human malaria parasite, Plasmodium falciparum. This parasite possesses the ability to convert in multiple stages in various hosts, cell types, and environments. Recent findings indicate that P. falciparum is talented at using efficient and complementary molecular mechanisms to ensure a tight control of gene expression at each stage of its life cycle. Here, we review the current understanding on the contribution of the epigenome, atypical transcription factors, and chromatin organization to regulate stage conversion in P. falciparum. The adjustment of these regulatory mechanisms occurring during the progression of the life cycle will be extensively discussed.
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