The (QxW)(3) domain: A flexible lectin scaffold
The (QxW)(3) domain: A flexible lectin scaffold
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DOI：
10.1002/pro.5560050805
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发表时间：
1996-08-01
期刊：
影响因子：
8
通讯作者：
Hazes, B
中科院分区：
文献类型：
--
作者：
Hazes, B
凝集素形成了一类蛋白质，这种蛋白质进化出了一种特殊的碳水化合物结合功能。根据氨基酸序列分析，已描述了几个凝集素家族，并在11个家族成员的基础上讨论了一个凝集素结构域--(QxW)(3)结构域。在本文中，(QxW)(3)结构域家族被扩展到45个序列，其中一些与该家族的已知成员具有很低的序列同源性。隐马尔可夫模型被用来识别该家族中分歧最大的成员。这组扩展的序列让我们更完整地了解了这个凝集素家族中保守的特征和缺乏的特征。这反过来又为各个家庭成员的结构和功能属性提供了新的见解。
Lectins form a class of proteins that have evolved a specialized carbohydrate-binding function. Based on amino acid sequence analysis, several lectin families have been described and a lectin domain, the (QxW)(3) domain, was discussed recently based on 11 family members. In this paper, the (QxW)(3) domain family is extended to 45 sequences, several of which have very low sequence identity with the previously known members of the family. A hidden Markov model was used to identify the most divergent members of the family. The expanded set of sequences gives us a more complete appreciation of the conserved features, and the lack thereof, in this lectin family. This, in turn, provides new insights in the structural and functional properties of the individual family members.