Pairing and anti-pairing: a balancing act in the diploid genome.
Pairing and anti-pairing: a balancing act in the diploid genome.
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DOI：
10.1016/j.gde.2016.03.002
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发表时间：
2016-04
影响因子：
4
通讯作者：
Wu CT
中科院分区：
文献类型：
--
作者：
Joyce EF;Erceg J;Wu CT
母本和父本同源物的存在似乎不仅仅是遗传物质的加倍。我们知道这一点是因为基因组已经进化出复杂的机制，允许同源区域感知并相互响应。同源物交流的一种方式是接触，事实上，果蝇等双翅目昆虫擅长这项任务，在整个发育过程中，基本上在所有体细胞组织中端到端地排列所有母本和父本染色体对。在这里，我们重新审视了广泛持有的原则，即同源序列的广泛体细胞配对不可能发生在哺乳动物中，并提出，配对可能是一种广泛且重要的潜力，但在哺乳动物中却未被注意到，因为它们花费了相当大的努力来阻止它。然后，我们将讨论扩展到一般的染色体间相互作用，并推测核组织和配对影响遗传的潜力。
The presence of maternal and paternal homologs appears to be much more than just a doubling of genetic material. We know this because genomes have evolved elaborate mechanisms that permit homologous regions to sense and then respond to each other. One way in which homologs communicate is to come into contact and, in fact, Dipteran insects such as Drosophila excel at this task, aligning all pairs of maternal and paternal chromosomes, end-to-end, in essentially all somatic tissues throughout development. Here, we reexamine the widely held tenet that extensive somatic pairing of homologous sequences cannot occur in mammals and suggest, instead, that pairing may be a widespread and significant potential that has gone unnoticed in mammals because they expend considerable effort to prevent it. We then extend this discussion to interchromosomal interactions, in general, and speculate about the potential of nuclear organization and pairing to impact inheritance.