Characterization of the coronary vascular β‐adrenoceptor in the pig
Characterization of the coronary vascular β‐adrenoceptor in the pig
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猪冠状血管β-肾上腺素受体的表征
DOI：
10.1111/j.1476-5381.1972.tb06880.x
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发表时间：
1972
影响因子：
7.3
通讯作者：
G. P. Levy
中科院分区：
文献类型：
--
作者：
G. M. Drew;G. P. Levy
猪冠状血管平滑肌中的β-肾上腺素受体的特征在于使用选择性激动剂沙丁胺醇和选择性拮抗剂普奈洛尔。在用 KCI 收缩的冠状动脉条中，沙丁胺醇仅具有边缘松弛活性，并且与异丙肾上腺素相比是部分激动剂。普奈洛尔对异丙肾上腺素具有相对较高的拮抗效力(pA(2) 6.59)。结论猪冠状血管β-肾上腺素受体属于β(1)型。
The beta-adrenoceptor in pig coronary vascular smooth muscle has been characterized by the use of a selective agonist, salbutamol and a selective antagonist, practolol. In coronary artery strips contracted with KCI, salbutamol had only marginal relaxant activity and was a partial agonist compared with isoprenaline. Practolol had relatively high antagonist potency against isoprenaline (pA(2) 6.59). It is concluded that the pig coronary vascular,beta-adrenoceptor is of the beta(1)-type.