Hydrogen proton magnetic resonance Spectroscopy in autism: Preliminary evidence of elevated choline/creatine ratio
Hydrogen proton magnetic resonance Spectroscopy in autism: Preliminary evidence of elevated choline/creatine ratio
复制标题
DOI：
10.1177/088307380201700401
复制
发表时间：
2002-04-01
影响因子：
1.9
通讯作者：
Feinberg, J
中科院分区：
文献类型：
--
作者：
Sokol, DK;Dunn, DW;Feinberg, J
氢质子磁共振波谱在自闭症患者中的研究才刚刚开始。我们报告，氢质子磁共振波谱胆碱/肌酸比值和自闭症的严重程度之间的关联，通过儿童自闭症评定量表（皮尔逊r =.657，P =.04）在10名自闭症儿童。氢质子磁共振波谱胆碱/肌酸比率测量细胞溶质胆碱的浓度，包括用于合成乙酰胆碱的游离胆碱。该比率的升高被解释为膜降解的结果，例如由肿瘤引起的，或者作为与增加的细胞增殖相关的胆碱合成的结果。最近的神经病理学证据表明，自闭症成年人大脑中的乙酰胆碱传递中断。氢质子磁共振波谱胆碱/肌酸比值的病例对照研究是必要的。
Hydrogen proton magnetic resonance spectroscopy is only beginning to be studied in autistic individuals. We report, an association between hydrogen proton magnetic resonance spectroscopy choline/creatine ratios and severity of autism as measured by the Children's Autistic Rating Scale (Pearson r =.657, P =.04) in 10 autistic children. Hydrogen proton magnetic resonance spectroscopy choline/creatine ratio measures the concentration of cytosolic choline including free choline used in the synthesis of acetylcholine. Elevation in this ratio has been interpreted as a result of membrane degradation such as caused by a tumor or, alternatively, as a result of choline synthesis associated with increased cellular proliferation. Recent neuropathologic evidence has implicated disruption of acetylcholine transmission in the brains of autistic adults. A case-controlled study of hydrogen proton magnetic resonance spectroscopy choline/creatine ratios is warranted.