Exosome levels in human body fluids: A tumor marker by themselves?
Exosome levels in human body fluids: A tumor marker by themselves?
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DOI：
10.1016/j.ejps.2016.09.010
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发表时间：
2017-01-01
影响因子：
4.6
通讯作者：
Fais, Stefano
中科院分区：
文献类型：
--
作者：
Cappello, Francesco;Logozzi, Mariantonia;Fais, Stefano
尽管进行了大量的研究工作，但寻找可靠的肿瘤生物标记物仍然具有挑战性和悬而未决。近年来，在细胞外纳米卵泡或外周小体中发现了一种新的具有高潜力的生物医学诊断工具。它们由大多数细胞释放，并包含有关来源细胞的详细分子信息，包括肿瘤特征。外切体可以从容易接触到的体液中分离出来，最重要的是，它们可以提供几个具有不同程度特异性的生物标志物。最近的临床证据表明，释放到体液中的外切体水平本身可能代表着肿瘤的预测/诊断，区分癌症患者和健康受试者。这篇综述的目的是强调这些最新的具有挑战性的发现，为成功的肿瘤早期诊断和随访提供新的和开创性的想法。(C)2016爱思唯尔B.V.保留所有权利。
Despite considerable research efforts, the finding of reliable tumor biomarkers remains challenging and unresolved. In recent years a novel diagnostic biomedical tool with high potential has been identified in extracellular nanovesicles or exosomes. They are released by the majority of the cells and contain detailed molecular information on the cell of origin including tumor hallmarks. Exosomes can be isolated from easy accessible body fluids, and most importantly, they can provide several biomarkers, with different levels of specificity. Recent clinical evidence shows that the levels of exosomes released into body fluids may themselves represent a predictive/diagnostic of tumors, discriminating cancer patients from healthy subjects. The aim of this review is to highlight these latest challenging findings to provide novel and ground breaking ideas for successful tumor early diagnosis and follow-up. (C) 2016 Elsevier B.V. All rights reserved.