Cooperative Lewis acid/N-heterocyclic carbene catalysis.
Cooperative Lewis acid/N-heterocyclic carbene catalysis.
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DOI：
10.1039/c1sc00621e
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发表时间：
2012-01-01
期刊：
影响因子：
8.4
通讯作者：
Scheidt KA
中科院分区：
文献类型：
--
作者：
Cohen DT;Scheidt KA
刘易斯酸活化与N-杂环卡宾（NHC）催化为不对称选择性反应的发展提供了新的机会。最近的研究结果表明，刘易斯酸可以发挥重要的作用，在homoenolate环化：增强的反应性，逆转的非对映体或区域选择性，并激活以前无活性的亲电试剂。此外，将刘易斯酸掺入到布朗斯特碱催化的共轭加成反应中可以提高产率。
Lewis acid activation with N-heterocyclic carbene (NHC) catalysis has presented new opportunities for enantioselective reaction development. Recent findings illustrate that Lewis acids can play an important role in homoenolate annulations by: enhancement of the reactivity, reversal of the diastereo- or regioselectivity, and activation of previously inactive electrophiles. Additionally, the incorporation of a Lewis acid into Brønsted base-catalyzed conjugate addition allowed for an increase in yields.