Distal radial fractures heal by direct woven bone formation.
Distal radial fractures heal by direct woven bone formation.
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DOI：
10.3109/17453674.2013.792769
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发表时间：
2013-06
影响因子：
3.7
通讯作者：
Sandberg O
中科院分区：
文献类型：
--
作者：
Aspenberg P;Sandberg O
骨折愈合的描述几乎只涉及轴骨折，他们经常强调软骨内骨形成。实际上，大多数骨折发生在干骺端松质骨。除了对椎体骨折的研究外，我们还没有发现任何人类松质骨愈合的组织学描述。我们研究了损伤后6-28天手术中获得的12例桡骨远端骨折中央部分的组织学活检，采用常规苏木精和伊红染色。新骨形成6例。它总是像胎儿一样，杂乱无章地编织着骨头。它很少与老小梁接触，似乎直接在骨髓中形成。软骨稀少或缺失。未成骨的标本仅表现为坏死、瘢痕或老松质骨。组织学表明，骨髓中的细胞对创伤的反应是直接形成骨，而不依赖于小梁表面。
Descriptions of fracture healing almost exclusively deal with shaft fractures and they often emphasize endochondral bone formation. In reality, most fractures occur in metaphyseal cancellous bone. Apart from a study of vertebral fractures, we have not found any histological description of cancellous bone healing in humans. We studied histological biopsies from the central part of 12 distal radial fractures obtained during surgery 6–28 days after the injury, using routine hematoxylin and eosin staining. New bone formation was seen in 6 cases. It was always in the form of fetal-like, disorganized woven bone. It seldom had contact with old trabeculae and appeared to have formed directly in the marrow. Cartilage was scarce or absent. The samples without bone formation showed only necrosis, scar, or old cancellous bone. The histology suggests that cells in the midst of the marrow respond to the trauma by direct formation of bone, independently of trabecular surfaces.