Evaluation of the Ez-HBT Helicobacter blood test to establish Helicobacter pylori eradication.
Evaluation of the Ez-HBT Helicobacter blood test to establish Helicobacter pylori eradication.
复制标题
评估 Ez-HBT 幽门螺杆菌血液检测以确定幽门螺杆菌根除情况。
DOI：
10.1111/j.1365-2036.2005.02655.x
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Wagner,DA
中科院分区：
文献类型：
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作者：
Ahmed,F;Murthy,UK;Chey,WD;Toskes,PP;Wagner,DA
Background: The urea blood test (Ez‐HBT) has been shown to compare favourably with the urea breath test in the diagnosis of activeHelicobacter pyloriinfection.Aim: To examine the performance characteristics of the Ez‐HBT Helicobacter blood test in establishing success or failure of therapy inH. pylori‐infected adults using the13C urea breath test as the reference method.Methods:13C urea breath test and Ez‐HBT Helicobacter blood test were performed 4–6 weeks after completion of treatment inH. pyloripositive subjects. Basal urea breath samples were collected; basal Ez‐HBT Helicobacter blood test samples were not. Ez‐HBT Helicobacter blood test results were reported as positive, negative, or indeterminate.Results: Seventy patients generated 126 measurable sets of urea breath and blood tests. TheH. pyloricure rate was 93%. The sensitivity, specificity, and accuracy of the Ez‐HBT Helicobacter blood test were 100%, 97%, and 97%, respectively. Six of eight false positive and indeterminate Ez‐HBT Helicobacter blood test results could be attributed to incomplete fasting or a13C enriched diet. After correcting for the non‐fasting state, the positive predictive value of the Ez‐HBT Helicobacter blood test improved from 56% to 86%.Conclusion: The performance characteristics of the Ez‐HBT Helicobacter blood test are comparable with that of13C‐urea breath test in establishingH. pylorieradication after therapy. Errors related to incomplete fasting can be mitigated by collection of a basal blood sample.
