Spontaneous activity in the perinatal trigeminal nucleus of the rat.
Spontaneous activity in the perinatal trigeminal nucleus of the rat.
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大鼠围产期三叉神经核的自发活动。
DOI：
10.1097/00001756-199902250-00039
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发表时间：
1999
期刊：
影响因子：
1.7
通讯作者：
P. Waite
中科院分区：
文献类型：
--
作者：
S. Ho;P. Waite
电活动在三叉神经通路中建立适当连接的作用仍然存在争议。我们在这里报告了一个新的观察自发活动在围产期三叉神经感觉核胚胎（E）16天至出生后（P）8天。大多数自发爆发具有相同的极性，并与三叉神经诱发反应的幅度相当。这种同步活动被荷包牡丹碱或犬尿烯酸废除。在自发爆发期间，从被戏弄的三叉神经根的记录也显示出相应的传入去极化。我们推测，GABA能去极化突触前和突触后细胞可能有助于产生的自发活动和其传播整个三叉神经感觉通路，即使在没有活动发起的外周感觉受体。
The role of electrical activity in establishing appropriate connections in the trigeminal pathway remains controversial. We report here a novel observation of spontaneous activity in the perinatal trigeminal sensory nucleus between embryonic day (E) 16 to postnatal day (P) 8. Most of these spontaneous bursts had the same polarity and were of comparable amplitude to the trigeminal nerve-evoked response. This synchronized activity was abolished by bicuculline or kynurenic acid. Recording from the teased trigeminal root during the spontaneous bursts also showed a corresponding afferent depolarization. We speculate that the GABAergic depolarization of pre- and postsynaptic cells may contribute to the generation of the spontaneous activity and its propagation throughout the trigeminal sensory pathway, even in the absence of activity initiated from peripheral sensory receptors.
大鼠个体三叉神经节细胞感受野的产前发育。
影响因子：
2.5
作者：
Chiaia,NL;Bauer,WR;Rhoades,RW
通讯作者：
Rhoades,RW