Development of a borondipyrromethene-based Zn2+ fluorescent probe: solvent effects on modulation sensing ability.
Development of a borondipyrromethene-based Zn2+ fluorescent probe: solvent effects on modulation sensing ability.
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DOI：
10.1039/c1dt10797f
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发表时间：
2012-01
影响因子：
4
通讯作者：
Chunchang Zhao;Yulin Zhang;Peng Feng;Jian Cao
中科院分区：
文献类型：
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作者：
Chunchang Zhao;Yulin Zhang;Peng Feng;Jian Cao
设计并合成了硼二吡咯亚甲基Zn(2+)荧光探针BODPAQ。 BODPAQ 中的螯合剂、2,2'-二吡啶胺 (DPA) 和 8-氨基喹啉 (AQ) 以协同方式与 Zn(2+) 配位。因此，由于 PET 和 ICT 机制的二元抑制效应，BODPAQ 显示出高 Zn(2+) 选择性，发射显着增强，并伴有显着的低色移，从而能够在乙腈中通过比例法和正常开启荧光方法检测 Zn(2+)。有趣的是，BODPAQ 对 Zn(2+) 的敏感性随着缓冲溶液组成的变化而变化。在3-吗啉代丙磺酸(MOPS)缓冲水溶液(50% CH(3)CN)中，BODPAQ对Zn(2+)表现出最高的灵敏度，而在柠檬酸盐-磷酸盐缓冲液中，BODPAQ对Zn(2+)没有反应。
A borondipyrromethene-based Zn(2+) fluorescent probe BODPAQ was designed and synthesized. The chelators in BODPAQ, 2,2'-dipicolylamine (DPA) and 8-aminoquinoline (AQ), coordinate to Zn(2+) in a synergic manner. As a result, BODPAQ displays high Zn(2+) selectivity with a dramatic enhanced emission accompanied by a notable hypsochromic shift due to the binary inhibition effect of PET and ICT mechanisms, enabling the detection of Zn(2+) by both ratiometric and normal turn-on fluorescence methods in acetonitrile. Interestingly, the sensitivity of BODPAQ towards Zn(2+) changes upon varying the compositions of buffer solutions. In 3-morpholinopropanesulfonic acid (MOPS) buffer aqueous solution (50% CH(3)CN), BODPAQ displays the highest sensitivity for Zn(2+), while in citrate-phosphate buffer, BODPAQ shows no response to Zn(2+).