B cells in the pathogenesis and treatment of rheumatoid arthritis.
B cells in the pathogenesis and treatment of rheumatoid arthritis.
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DOI：
10.1097/bor.0b013e3283369cb8
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发表时间：
2010-05
影响因子：
5.1
通讯作者：
Anolik JH
中科院分区：
文献类型：
--
作者：
Marston B;Palanichamy A;Anolik JH
我们对 B 细胞在类风湿性关节炎中的多种生理和致病功能的了解不断扩大。反过来，针对 B 细胞区室的有效药物的可用性也会增加。在这篇综述中，我们讨论了 B 细胞在 RA 中的作用的新见解，以及有关 B 细胞耗竭和治疗反应生物标志物功效的最新证据。最近的数据进一步阐明了类风湿滑膜中异位淋巴结构生成的要求、它们的频率以及在发病机制中的作用。其他研究描述了滑膜中浸润 B 细胞的表型以及 B 细胞在骨稳态中意想不到的作用。除了 B 细胞的致病作用外，还有越来越多的证据表明调节性 B 细胞亚群可能发挥保护作用。关于放射学进展、早期疾病疗效、再治疗的作用和治疗反应生物标志物的新数据继续完善 B 细胞耗竭在治疗装备中的作用。过去几年，免疫学在 RA 研究中取得了新进展，对病因学和发病机制产生了令人惊讶的观察结果和有趣的新见解。
Our understanding of the multiple physiological and pathogenic functions of B cells in rheumatoid arthritis continues to expand. In turn, the availability of effective agents targeting the B cell compartment increases. In this review, we discuss novel insights into the roles of B cells in RA and recent evidence regarding the efficacy of B cell depletion and biomarkers of treatment response. Recent data has further elucidated the requirements for the generation of ectopic lymphoid structures in the rheumatoid synovium, their frequency, and role in pathogenesis. Additional studies have described the phenotype of infiltrating B cells in the synovium and the unexpected role for B cells in bone homeostasis. In addition to pathogenic roles for B cells, there is also mounting evidence for regulatory B cell subsets that may play a protective role. New data on radiographic progression, efficacy in early disease, the role of re-treatment, and biomarkers of treatment response continue to refine the role of B cell depletion in the treatment armamentarium. The past few years have seen new advances in immunology applied to the study of RA with surprising observations and interesting new insights into etiology and pathogenesis.