THE CONCEPTS OF CROSSREACTIVITY AND SPECIFICITY IN IMMUNOLOGY
THE CONCEPTS OF CROSSREACTIVITY AND SPECIFICITY IN IMMUNOLOGY
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DOI：
10.1016/0161-5890(81)90067-5
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发表时间：
1981-01-01
影响因子：
3.6
通讯作者：
SCHECHTER, AN
中科院分区：
文献类型：
--
作者：
BERZOFSKY, JA;SCHECHTER, AN
用于研究动物IG和抗原的相互作用的直接结合测定的出现使得区分几种类型的交叉反应性变得重要。综述了交叉反应的分子基础，并详细分析了这些不同过程在通常用于放射免疫分析的位移曲线中的行为。必须明确考虑抗原的结构和抗体的同质性或异质性。免疫特异性可以通过类似的推理来定义。这些概念代表了蛋白质化学原理的应用，在描述溶液中分子与细胞受体的相互作用时应该是有用的。
The advent of direct binding assays for studying the interactions of animal Ig and antigens has made it important to distinguish among several types of crossreactivity. The molecular basis of crossreactivity is reviewed, and the behavior of these different processes in the displacement curves ordinarily used for radioimmunoassay is analyzed in detail. Both the structure of the antigens and the homogeneity or heterogeneity of the antibodies must be explicitly considered. Immunological specificity may be defined by similar reasoning. These concepts, which represent applications of the principles of protein chemistry, should be useful in describing the interactions of molecules in solution with cell receptors.