GHetting to know ADPKD proliferative signaling, STAT.
GHetting to know ADPKD proliferative signaling, STAT.
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GHetting 了解 ADPKD 增殖信号传导，STAT。
DOI：
10.1016/j.kint.2016.11.024
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发表时间：
2017
影响因子：
19.6
通讯作者：
Weiss,RobertH
中科院分区：
文献类型：
--
作者：
Chen,Ching-Hsien;Weiss,RobertH
由于其共同的发病机制和相似的增殖信号通路，囊性疾病近年来在癌症生物学的背景下得到了广泛的研究。目前的研究通过确定转录信号换能器和激活因子（STAT5）和生长激素（GH）作为多囊肾病的潜在可改变途径，延续了这一范式。生长激素是一种有效的STAT5激活剂，有可能成为一种生物标志物，并在临床试验中提供生长抑素类似物的潜在作用机制。
Due to their common pathogenesis and parallel proliferative signaling pathways, the cystic diseases have been recently studied in the context of cancer biology. The present study continues this paradigm by identifying signal transducer and activator of transcription (STAT5) and growth hormone (GH) as potentially modifiable pathways in polycystic kidney disease. GH, which is a potent activator of STAT5, has the additional possibility of being a biomarker, as well as providing a potential mechanism of action of somatostatin analogs in clinical trials.