Decline in insulin-like growth factor-I levels across adult life span in two large population studies.
Decline in insulin-like growth factor-I levels across adult life span in two large population studies.
复制标题
在两项大型人群研究中，成人寿命期间胰岛素样生长因子 I 水平下降。
DOI：
10.1093/gerona/61.2.182
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Metter,EJeffrey
中科院分区：
文献类型：
--
作者：
Maggio,Marcello;Ble,Alessandro;Ceda,GianPaolo;Metter,EJeffrey
胰岛素样生长因子- i （IGF-I）是一种合成代谢激素，主要参与生命最初20年的骨骼和肌肉发育。最近的研究表明，在老年人中，较低的igf - 1水平与残疾、全因死亡(1)和心血管死亡(2)的风险增加有关。研究表明，igf - 1血清水平在人的一生中会下降（3-5岁），但人群中年龄特异性的平均水平仍不确定。此外，还不清楚年下降率是恒定的还是随着年龄的增长而增加。在本报告中，我们比较了IGF-I浓度在整个成人生命周期中与年龄相关的变化趋势
Insulin-like growth factor-I (IGF-I) is an anabolic hormone primarily involved in skeleton and muscle development during the first two decades of life. Recent studies suggest that, in older persons, lower IGF-I levels are associated with an increased risk of disability and all-cause (1) and cardiovascular mortality (2).Studies have suggested that IGF-I serum levels decline over the life span (3–5), but age-specific average levels in the population are still undefined. Additionally, it is unclear whether the annual rate of decline is constant or becomes higher at older ages. In the present report, we compared trends of age-related changes of IGF-I concentration across the adult life span from cross-sectional data collected in