Antigen‐specific T‐cell activation in hyperplastic thymus in myasthenia gravis
Antigen‐specific T‐cell activation in hyperplastic thymus in myasthenia gravis
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DOI：
10.1002/mus.20794
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发表时间：
2007-07
期刊：
影响因子：
3.4
通讯作者：
K. Utsugisawa;Y. Nagane;Shigeaki Suzuki;R. Kondoh
中科院分区：
文献类型：
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作者：
K. Utsugisawa;Y. Nagane;Shigeaki Suzuki;R. Kondoh
为了确定早期起病重症肌无力(EOMG)患者淋巴滤泡增生胸腺中树突状细胞(DC)抗原特异性T细胞活化是否加速，我们研究了早发性重症肌无力(EOMG)患者胸腺、晚发性MG患者残留胸腺和非MG对照胸腺标本中磷酸化蛋白激酶C(PKC)θ的表达水平及其与成熟DC标志物归巢受体CD44或CD83的局部关系。EOMG患者TLFH中抗原特异性T细胞活化明显加快。活化的T细胞和邻近的DC似乎是从血液循环到胸腺的CD44高细胞群的组成部分。虽然没有令人信服的证据表明胸腺切除术对MG有好处，但在一些胸腺切除术后早期好转的EOMG患者中，CD44相关循环机制的阻断可能是胸腺切除术早期益处的原因，是胸腺切除术的潜在替代方案。肌肉神经，2007年
In order to determine whether antigen‐specific T‐cell activation by dendritic cells (DCs) is accelerated in thymuses exhibiting lymphofollicular hyperplasia (TLFH) among patients with early‐onset myasthenia gravis (EOMG), we investigated the expression levels of phosphorylated protein kinase C (PKC)θ and the local relationship between the presence of phosphorylated PKCθ and the homing receptor CD44 or CD83, a marker for mature DCs, in samples taken from EOMG patients with early improvement following thymectomy, in remnant thymuses from late‐onset MG patients, and in non‐MG control thymuses. Antigen‐specific T‐cell activation was markedly accelerated in TLFH from EOMG patients. Activated T cells and adjacent DCs appeared to be components of a CD44high cell population circulating from the blood to the thymus. Although there is no convincing evidence that thymectomy is of benefit in MG, in some EOMG patients with early improvement following thymectomy, blockade of CD44‐associated circulation mechanisms is probably the cause for the early benefits of thymectomy and is a potential alternative to thymectomy. Muscle Nerve, 2007