Morphological evaluation of soft tissue augmentation by using porous poly-DL-lactic acid with straight holes
Morphological evaluation of soft tissue augmentation by using porous poly-DL-lactic acid with straight holes
复制标题
直孔多孔聚DL-乳酸软组织填充的形态学评价
DOI：
10.1097/id.0000000000000480
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发表时间：
2016
影响因子：
--
通讯作者：
Kasugai Shohei
中科院分区：
文献类型：
--
作者：
Yukawa Ken;Tachika Noriko;Furuichi Akiko;Kasugai Shohei
目的：研究多孔聚乳酸（PDLLA）多孔支架在软组织填充中的生物反应。材料与方法：对照组为直径5.0 mm，高度2.0 mm的多孔PDLLA。2个试验组，支架底部由上至下依次钻孔7个孔；孔直径分别为0.5和1.0 mm。在头盖骨骨膜内放置支架。在第4周和第8周测定支架的高度和分子量。苏木精和伊红染色测定结缔组织和血管面积。结果：各组支架高度相近，但随着时间的推移，Mw明显降低。在同一时间点，对照组、0.5 mm组和1.0 mm组的结缔组织和血管面积有显著差异。通过在支架上钻孔增加软组织。结论：多孔聚乳酸（PDLLA）具有良好的软组织预后。孔洞越宽，结缔组织和血管面积越大。支架高度和Mw不受孔大小的影响。
Objectives:This study investigated the biological reaction to porous poly-DL-lactic acid (PDLLA) scaffolds with holes for soft tissue augmentation.Materials and Methods:The control group was porous PDLLA with a diameter of 5.0 mm and a height of 2.0 mm. For the 2 test groups, 7 holes were drilled from the upper to the lower base of the scaffolds; the holes had diameters of 0.5 and 1.0 mm. A scaffold was placed in the periosteum of the cranium. The height and molecular weight (Mw) of the scaffolds were measured at 4 and 8 weeks. Hematoxylin and eosin staining was used to measure the connective tissue and blood vessel areas.Results:All groups had similar scaffold heights, but the Mw decreased significantly over time. There were significant differences in the connective tissue and blood vessel areas among the control, 0.5-mm, and 1.0-mm groups at the same time point. The soft tissue was increased by drilling holes in the scaffolds.Conclusion:Porous poly-DL-lactic acid (PDLLA) contributed favorable prognosis for soft tissue. A wider hole was associated with increased connective tissue and blood vessel areas. The scaffold height and Mw were not impacted by size of the holes.