Lymphorna incidence patterns by WHO subtype in the United States, 1992-2001
Lymphorna incidence patterns by WHO subtype in the United States, 1992-2001
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DOI：
10.1182/blood-2005-06-2508
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发表时间：
2006-01-01
期刊：
影响因子：
20.3
通讯作者：
Linet, MS
中科院分区：
文献类型：
--
作者：
Morton, LM;Wang, SS;Linet, MS
由于大多数淋巴样肿瘤的病因尚不清楚，按疾病亚型比较发病率模式可能为未来的病因调查提供重要线索。因此，我们根据2001年引入的国际公认的世界卫生组织（WHO）淋巴瘤分类，对1992-2001年12个监测、流行病学和最终结果（SEER）登记处诊断的114548例淋巴肿瘤进行了全面评估。按照国际肿瘤疾病分类第二版（ICD-O-2）编码的病例被转换为WHO亚型分配的ICD-O-3。按性别和种族（白人、黑人、亚洲人）比较特定年龄和年龄调整后的比率。使用加权最小二乘对数线性回归估计按性别和种族调整年龄的发病率趋势。淋巴样肿瘤不同亚型和不同人群的发病模式和趋势不同。在老年人（75岁或以上）中，弥漫性大b细胞淋巴瘤（DLBCL）和滤泡性淋巴瘤的发病率每年分别增加1.4%和1.8%，而慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLUSLL）的发病率每年下降2.1%。尽管白人在大多数淋巴肿瘤亚型中发病率最高，尤其是毛细胞白血病和滤泡性淋巴瘤，但在浆细胞和t细胞肿瘤中观察到黑色优势。亚洲人患CLL/SLL和霍奇金淋巴瘤的比例明显低于白人和黑人。我们的结论是，组织学亚型在发病率模式上的显著差异强烈表明淋巴样肿瘤之间存在病因异质性，并支持按亚型进行流行病学分析。
Because the causes of most lymphoid neoplasms remain unknown, comparison of incidence patterns by disease subtype may provide critical clues for future etiologic investigations. We therefore conducted a comprehensive assessment of 114548 lymphold neoplasms diagnosed during 1992-2001 in 12 Surveillance, Epidemiology, and End Results (SEER) registries according to the internationally recognized World Health Organization (WHO) lymphoma classification introduced in 2001. Cases coded in International Classification of Diseases for Oncology, Second Edition (ICD-O-2), were converted to ICD-O-3 for WHO subtype assignment. Age-specific and age-adjusted rates were compared by sex and race (white, black, Asian). Age-adjusted trends in incidence were estimated by sex and race using weighted least squares log-linear regression. Diverse incidence patterns and trends were observed by lymphoid neoplasm subtype and population. In the elderly (75 years or older), rates of diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma increased 1.4% and 1.8% per year, respectively, whereas rates of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLUSLL) declined 2.1% per year. Although whites bear the highest incidence burden for most lymphold neoplasm subtypes, most notably for hairy cell leukemia and follicular lymphoma, black predominance was observed for plasma cell and T-cell neoplasms. Asians have considerably lower rates than whites and blacks for CLL/SLL and Hodgkin lymphoma. We conclude that the striking differences in incidence patterns by histologic subtype strongly suggest that there is etiologic heterogeneity among lymphoid neoplasms and support the pursuit of epidemiologic analysis by subtype.