Evaluation of puberty by verifying spontaneous and stimulated gonadotropin values in girls.
Evaluation of puberty by verifying spontaneous and stimulated gonadotropin values in girls.
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DOI：
10.1515/jpem-2014-0135
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发表时间：
2015-03
期刊：
影响因子：
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通讯作者：
Zhou P
中科院分区：
文献类型：
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作者：
Chin VL;Cai Z;Lam L;Shah B;Zhou P
药理药物的变化和实验室检测的进步已经改变了促性腺激素释放激素类似物刺激试验。目的：确定检测女孩青春期的最佳预测模型。35例女孩，年龄2岁7个月~9岁3个月，伴有中枢性性早熟(CPP)(n=20)或胸廓/肾上腺早熟(n=15)。诊断基于临床信息、基线激素、骨龄和骨盆超声。用免疫化学发光法测定促性腺激素和雌二醇。对CPP进行Logistic回归分析。CPP的最佳预测因子是基于3至24小时的E2变化模型，提供80%的灵敏度和87%的特异度。黄体生成素(LH)三小时检测的敏感性和特异性分别为75%和87%。基础促黄体生成素使敏感性降至65%，特异性降至53%。E_2变化模型具有最好的预测能力，而3小时黄体生成素在评估女孩青春期时更为实用和方便。
Changes in pharmacological agents and advancements in laboratory assays have changed the gonadotropin-releasing hormone analog stimulation test. To determine the best predictive model for detecting puberty in girls. Thirty-five girls, aged 2 years 7 months to 9 years 3 months, with central precocious puberty (CPP) (n = 20) or premature thelarche/premature adrenarche (n = 15). Diagnoses were based on clinical information, baseline hormones, bone age, and pelvic sonogram. Gonadotropins and E2 were analyzed using immunochemiluminometric assay. Logistic regression for CPP was performed. The best predictor of CPP is the E2-change model based on 3- to 24-h values, providing 80% sensitivity and 87% specificity. Three-hour luteinizing hormone (LH) provided 75% sensitivity and 87% specificity. Basal LH lowered sensitivity to 65% and specificity to 53%. The E2-change model provided the best predictive power; however, 3-h LH was more practical and convenient when evaluating puberty in girls.