Mesenchymal Stem Cell Therapy and Delivery Systems in Nonhealing Wounds
Mesenchymal Stem Cell Therapy and Delivery Systems in Nonhealing Wounds
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DOI：
10.1097/01.asw.0000407648.89961.a6
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发表时间：
2011-11-01
影响因子：
2.4
通讯作者：
Chen, Weiliam
中科院分区：
文献类型：
--
作者：
Brower, Jonathan;Blumberg, Sheila;Chen, Weiliam
目的：本研究的目的是告知伤口护理从业者间充质干细胞应用于不愈合伤口。资料来源：在MEDLINE和PubMed Central中检索关于间充质干细胞和递送系统在伤口愈合中的应用的科学研究。资料选择：选择了使用干细胞作为慢性伤口治疗方式的临床前研究。资料提炼：信息研究设计，样本量和特点，干细胞来源，类型的交付系统，和速度和时间的伤口闭合abstracted.DATA综合：应用间充质干细胞改善伤口愈合的实验和临床设置。干细胞治疗和运载工具的进展提供了有前途的替代品，目前有限的治疗方式为慢性wounds.CONCLUSIONS：干细胞治疗最近出现了作为一个有前途的治疗策略nonhealing伤口。需要进一步的研究来评估各种递送系统和干细胞之间的关系，以最大限度地提高其治疗效果。开发新型干细胞递送载体可以为更有效的慢性伤口细胞治疗开辟新的机会。
OBJECTIVE: The objective of the study was to inform wound care practitioners of mesenchymal stem cell application for nonhealing wounds. Recent advances in delivery systems are also discussed in order to highlight potential improvements toward clinical application of stem cell therapy for chronic wounds.DATA SOURCES: MEDLINE and PubMed Central were searched for scientific studies regarding the use of mesenchymal stem cells and delivery systems in wound healing.STUDY SELECTION: Preclinical studies using stem cells as therapeutic modality for chronic wounds were selected for this review.DATA EXTRACTION: Information on study design, sample size and characteristics, stem cell source, type of delivery systems, and rate and time of wound closure was abstracted.DATA SYNTHESIS: Application of mesenchymal stem cells improved wound healing in experimental and clinical settings. Advances in stem cell therapy and delivery vehicles offer promising alternatives to current limited therapeutic modalities for chronic wounds.CONCLUSIONS: Stem cell therapy has recently emerged as a promising therapeutic strategy for nonhealing wounds. Further research is needed to evaluate the relationship between the various delivery systems and stem cells in order to maximize their therapeutic effects. Development of novel delivery vehicles for stem cells can open new opportunities for more effective cell therapy of chronic wounds.