De-novo brain tumours in renal-transplant recipients.
De-novo brain tumours in renal-transplant recipients.
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肾移植受者的新生脑肿瘤。
DOI：
10.1016/s0140-6736(71)91384-5
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发表时间：
1971
期刊：
影响因子：
168.9
通讯作者：
I. Penn
中科院分区：
文献类型：
--
作者：
S. Schneck;I. Penn
在全世界器官同种移植患者中新发的24种间质肿瘤中，有11种涉及脑。在8例病例中，肿瘤仅存在于该器官中。9例为网状细胞肉瘤，2例为未分类淋巴瘤。这些病变在移植后比非脑间质或上皮肿瘤更早出现。大脑没有淋巴系统，除非事先免疫，否则对外来抗原的反应性细胞很少增殖。这表明肿瘤细胞可能产生于大脑本身或从其他部位携带到那里。未免疫和免疫抑制的大脑的免疫反应较差，这表明肿瘤细胞在这种相对免疫特权的环境中比在其他组织中更容易生长的可能性。
11 of 24 mesenchymal neoplasms which have arisen de novo in patients with organ homografts throughout the world have involved the brain. In 8 cases the tumours were present only in this organ. 9 neoplasms were reticulumcell sarcomas and 2 were unclassified lymphomas. These lesions appeared sooner after transplantation than did non-cerebral mesenchymal or epithelial tumours. The brain has no lymphatic system, and little proliferation of reactive cells takes place in response to foreign antigens unless prior immunisation has occurred. It is suggested that tumour cells could arise in the brain itself or be carried there from other sites. The poor immunological reactions of the unimmunised and immunosuppressed brain suggest the possibility that neoplastic cells would grow more readily in this relatively immunologically privileged environment than in other tissues.