The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review).
The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review).
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DOI：
10.3892/ijo.2016.3427
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发表时间：
2016-05
影响因子：
5.2
通讯作者：
Jeon JH
中科院分区：
文献类型：
--
作者：
Cho M;So I;Chun JN;Jeon JH
香叶醇是在芳香植物的精油中发现的膳食单萜醇。迄今为止，实验证据支持香叶醇对不同类型的癌症，如乳腺癌、肺癌、结肠癌、前列腺癌、胰腺癌和肝癌的治疗或预防作用，并揭示了其药理作用的机制基础。此外，香叶醇使肿瘤细胞对常用的化疗剂敏感。香叶醇控制代表肿瘤标志的多种信号分子和途径;香叶醇的这些作用限制了肿瘤细胞获得对抗癌药物的适应性抗性的能力。在本综述中，我们强调，香叶醇是一个有前途的化合物或化学部分的发展，一个安全，有效的多靶点抗癌剂。我们总结了当前的知识香叶醇对靶分子和途径的影响，在癌细胞。我们的审查提供了新的见解的挑战和前景方面的香叶醇的研究和其在未来的临床研究中的应用。
Geraniol is a dietary monoterpene alcohol that is found in the essential oils of aromatic plants. To date, experimental evidence supports the therapeutic or preventive effects of geraniol on different types of cancer, such as breast, lung, colon, prostate, pancreatic, and hepatic cancer, and has revealed the mechanistic basis for its pharmacological actions. In addition, geraniol sensitizes tumor cells to commonly used chemotherapy agents. Geraniol controls a variety of signaling molecules and pathways that represent tumor hallmarks; these actions of geraniol constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs. In the present review, we emphasize that geraniol is a promising compound or chemical moiety for the development of a safe and effective multi-targeted anticancer agent. We summarize the current knowledge of the effects of geraniol on target molecules and pathways in cancer cells. Our review provides novel insight into the challenges and perspectives with regard to geraniol research and to its application in future clinical investigation.