Role of apoptosis in disease.
Role of apoptosis in disease.
复制标题
DOI：
10.18632/aging.100459
复制
发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
De Laurenzi V
中科院分区：
文献类型：
--
作者：
Favaloro B;Allocati N;Graziano V;Di Ilio C;De Laurenzi V
自从细胞凋亡的最初描述以来，已经描述了许多不同形式的细胞死亡。在这篇综述中，我们将集中在经典的半胱天冬酶依赖性细胞凋亡及其变化，有助于疾病。超过50年的研究已经阐明了参与凋亡信号传导的分子机制，并表明这些途径的改变导致人类疾病。事实上，细胞凋亡的减少和增加都可能导致病理学。最近，这些发现导致了基于细胞凋亡调节的治疗方法的发展，其中一些正在临床试验中或已进入医疗实践。
Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling as well and shown that alterations of these pathways lead to human diseases. Indeed both reduced and increased apoptosis can result in pathology. More recently these findings have led to the development of therapeutic approaches based on regulation of apoptosis, some of which are in clinical trials or have entered medical practice.