Ageing of the human entorhinal cortex and subicular complex.
Ageing of the human entorhinal cortex and subicular complex.
复制标题
人类内嗅皮层和皮下复合体的老化。
DOI：
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发表时间：
1992
影响因子：
2
通讯作者：
L. M. Gonzalo
中科院分区：
文献类型：
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作者：
L. Trillo;L. M. Gonzalo
对30例14~86岁脑死亡患者的内嗅皮层(EC)和下丘脑束复合体(SC)的年龄相关性变化进行了研究，大体和显微检查均无中枢神经系统损害。大脑固定在10%的福尔马林中，石蜡包埋。3组EC和SC冠状切片(7微米)尼氏染色、PAS染色或苏木精-伊红染色。用神经元计数和卡氏计量学方法，研究了EC外侧区II、III、V层、下丘(S)锥体层和丘脑前(PS)II层随年龄变化的变化。所有被研究的EC蛋鸡在35岁以下都有轻微的下降(11-20%)，但从35岁到75岁下降并不显著。75年后，神经元丢失略有增加。核面积在40~45岁时缩小(10~18%)，在75岁时增大(10~14%)。在生命的最后阶段，核区没有改变。30~60岁时，S区锥体细胞层出现明显的神经元丢失(30%)，以后神经元减少较少。早期，核面积减少不明显(15%)，从35岁到研究的最高年龄，核面积显著增加(13%)。在PS中，第II层在整个生命周期中表现为细胞丢失(32.9%)，由于其数值的分散性，核面积的变化没有达到统计学意义。
Age-dependent changes in the entorhinal cortex (EC) and subicular complex (SC) were studied in 30 brains of patients who died between 14 and 86 years of age, without CNS impairment, as determined by macro- and microscopic examination. The brains were fixed in 10% formalin and embedded in paraffin. Three series of coronal EC and SC sections (7 microns) were stained by Nissl, PAS or hematoxylin-eosin. Using neuronal count and Kariometry, age-dependent modifications were studied in layers II, III and V of the lateral area of the EC; in the pyramidal layer of the subiculum (S), and in layer II of the presubiculum (PS). All EC layers studied presented a slight (11-20%) although significant reduction up to 35 years, but from 35 to 75 years the decrease was not significant. After 75 years the neuronal loss increased slightly. The nuclear area decreased up to the age of 40-45 years, (10-18%) and augmented from this age up to 75 years (10-14%). During the last period of life, the nuclear area did not change. From 30-60 years, pyramidal layer in the S showed a significant neuronal loss (30%), thereafter, neuronal reduction was less. At early years, the nuclear area decreased insignificantly (15%), and from 35 years up to the most advanced age studied, it increased significantly (13%). In the PS, layer II manifested a cell loss throughout the lifespan (32.9%) and the changes in the nuclear area did not reach statistical significance due to the dispersions of its values.(ABSTRACT TRUNCATED AT 250 WORDS)