OncoLnc: linking TCGA survival data to mRNAs, miRNAs, and lncRNAs
OncoLnc: linking TCGA survival data to mRNAs, miRNAs, and lncRNAs
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DOI：
10.7717/peerj-cs.67
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发表时间：
2016-06-01
影响因子：
3.8
通讯作者：
Anaya, Jordan
中科院分区：
文献类型：
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作者：
Anaya, Jordan
OncoLnc是一个交互式探索生存相关性的工具，用于下载与mrna、mirna或长链非编码rna （lncrna）表达数据耦合的临床数据。OncoLnc包含来自癌症基因组图谱（TCGA）进行的21项癌症研究的8,647名患者的生存数据，以及TCGA mrna和mirna的RNA-SEQ表达和MiTranscriptome β的lncRNA表达。存储这些数据使用户能够通过基因表达分离患者，然后创建出版质量的Kaplan-Meier图或下载数据进行进一步分析。OncoLnc还存储预先计算的生存分析，允许用户在一次点击中快速探索多达21种癌症的生存相关性。该资源允许研究特定基因的研究人员快速调查它是否可能在癌症中起作用，并且支持数据允许研究特定癌症的研究人员识别与生存最相关的mrna， mirna和lncRNA，以及研究人员寻找与癌症相关的新型lncRNA的潜在候选名单。
OncoLnc is a tool for interactively exploring survival correlations, and for downloading clinical data coupled to expression data for mRNAs, miRNAs, or long noncoding RNAs (lncRNAs). OncoLnc contains survival data for 8,647 patients from 21 cancer studies performed by The Cancer Genome Atlas (TCGA), along with RNA-SEQ expression for mRNAs and miRNAs from TCGA, and lncRNA expression from MiTranscriptome beta. Storing this data gives users the ability to separate patients by gene expression, and then create publication-quality Kaplan-Meier plots or download the data for further analyses. OncoLnc also stores precomputed survival analyses, allowing users to quickly explore survival correlations for up to 21 cancers in a single click. This resource allows researchers studying a specific gene to quickly investigate if it may have a role in cancer, and the supporting data allows researchers studying a specific cancer to identify the mRNAs, miRNAs, and lncRNAs most correlated with survival, and researchers looking for a novel lncRNA involved with cancer lists of potential candidates.