Seasonal changes of perineuronal nets and song learning in adult canaries (Serinus canaria)
Seasonal changes of perineuronal nets and song learning in adult canaries (Serinus canaria)
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DOI：
10.1016/j.bbr.2019.112437
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发表时间：
2020-02-17
影响因子：
2.7
通讯作者：
Balthazart, Jacques
中科院分区：
文献类型：
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作者：
Cornez, Gilles;Collignon, Clementine;Balthazart, Jacques
鸣禽在与增强的神经可塑性相关的敏感发育期学习它们的歌曲。此外，在开放式的学习者，如金丝雀，感觉运动声乐学习的敏感期每年秋季重新开放，并导致连续繁殖季节之间的歌曲修改。在成年金丝雀的歌曲生产中观察到的变化与睾酮浓度的季节性波动和细胞核的歌曲控制系统（SCS）的形态变化相关。在个体发育过程中，然后再次在成年期的歌曲学习的敏感期可以控制周围的小白蛋白表达的interneurones（PV），这限制了学习诱导的神经可塑性的神经元围神经元网络（PNN）的发展。然而，这种关系从未在成年鸣禽的成年发声学习背景下进行过研究。在这里，我们探讨了PNN和PV的表达在SCS的成年男性法夫花式金丝雀的季节性变化，他们的歌唱行为。我们发现了睾丸激素浓度和歌曲产生的季节性变化的明确模式。此外，PNN的表达显着较高的两个特定的歌曲控制核，强大的核arcopallium（RA）和基底神经节的X区，在繁殖季节和感觉运动的歌曲发展的后期阶段相比，鸟类在早期阶段的感觉运动的发展在秋季。这些数据提供了第一个证据表明，PNN表达的变化可能代表了一种机制，调节成年鸣禽跨季节的声乐学习敏感期的关闭-重新开放。
Songbirds learn their song during a sensitive period of development associated with enhanced neural plasticity. In addition, in open-ended learners such as canaries, a sensitive period for sensorimotor vocal learning reopens each year in the fall and leads to song modifications between successive breeding seasons. The variability observed in song production across seasons in adult canaries correlates with seasonal fluctuations of testosterone concentrations and with morphological changes in nuclei of the song control system (SCS). The sensitive periods for song learning during ontogeny and then again in adulthood could be controlled by the development of perineuronal nets (PNN) around parvalbumin-expressing interneurones (PV) which limits learning-induced neuroplasticity. However, this relationship has never been investigated in the context of adult vocal learning in adult songbirds. Here we explored PNN and PV expression in the SCS of adult male Fife Fancy canaries in relation to the seasonal variations of their singing behaviour. We found a clear pattern of seasonal variation in testosterone concentrations and song production. Furthermore, PNN expression was significantly higher in two specific song control nuclei, the robust nucleus of the arcopallium (RA) and the Area X of the basal ganglia, during the breeding season and during the later stages of sensorimotor song development compared to birds in an earlier stage of sensorimotor development during the fall. These data provide the first evidence that changes in PNN expression could represent a mechanism regulating the closing-reopening of sensitive periods for vocal learning across seasons in adult songbirds.