Tissue-mimicking thermochromic phantom for characterization of HIFU devices and applications
Tissue-mimicking thermochromic phantom for characterization of HIFU devices and applications
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DOI：
10.1080/02656736.2019.1605458
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发表时间：
2019-01-01
影响因子：
3.1
通讯作者：
Partanen, Ari
中科院分区：
文献类型：
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作者：
Eranki, Avinash;Mikhail, Andrew S.;Partanen, Ari
目的：仿组织模型（Tissue-mimicking phantomy，TMPs）是一种人工合成的生物组织模拟材料。需要量化超声或磁共振成像引导的高强度聚焦超声（MR-HIFU）后的温度变化。本工作描述了开发，表征和评价的组织模仿热致变色体模（TMTCP）的直接可视化和量化的HIFU加热。目的是（1）开发一种可报告绝对温度的MR成像、HIFU兼容的TMTCP，（2）表征TMTCP的物理特性，（3）检查HIFU后TMTCP的颜色变化。方法和材料：制备了一种含有热致变色油墨、二氧化硅和牛血清白蛋白（BSA）的TMTCP，并对其性能进行了量化。使用临床MRI引导和临床前US引导的HIFU系统在TMTCP中进行超声处理。在HIFU期间进行MRI测温，然后在HIFU后进行T2加权MRI。将颜色和信号强度变化的位置与超声处理计划和MRI温度图进行比较。结果：TMTCP的性能与人体软组织中的性能相当。在加热时，TMTCP在45至70摄氏度之间的温度下表现出增量但永久的颜色变化。对于HIFU超声治疗，TMTCP显示了靶位置处颜色变化的空间尖锐区域，与MRI测温和T2加权MRI上的低信号区域相关。还证明了基于TMTCP的各种HIFU应用的评估。结论：我们开发了一种新的MR成像和HIFU兼容的TMTCP来表征HIFU加热，而无需MRI或热电偶。HIFU优化的TMTCP以高空间分辨率报告绝对温度和消融区几何形状。因此，TMTCP可用于评估HIFU加热，并可提供峰值温度评估的体外工具，并降低临床转化的临床前体内要求。
Purpose: Tissue-mimicking phantoms (TMPs) are synthetic materials designed to replicate properties of biological tissues. There is a need to quantify temperature changes following ultrasound or magnetic resonance imaging-guided high intensity focused ultrasound (MR-HIFU). This work describes development, characterization and evaluation of tissue-mimicking thermochromic phantom (TMTCP) for direct visualization and quantification of HIFU heating. The objectives were to (1) develop an MR-imageable, HIFU-compatible TMTCP that reports absolute temperatures, (2) characterize TMTCP physical properties and (3) examine TMTCP color change after HIFU. Methods and materials: A TMTCP was prepared to contain thermochromic ink, silicon dioxide and bovine serum albumin (BSA) and its properties were quantified. A clinical MRI-guided and a preclinical US-guided HIFU system were used to perform sonications in TMTCP. MRI thermometry was performed during HIFU, followed by T2-weighted MRI post-HIFU. Locations of color and signal intensity change were compared to the sonication plan and to MRI temperature maps. Results: TMTCP properties were comparable to those in human soft tissues. Upon heating, the TMTCP exhibited an incremental but permanent color change for temperatures between 45 and 70 degrees C. For HIFU sonications the TMTCP revealed spatially sharp regions of color change at the target locations, correlating with MRI thermometry and hypointense regions on T2-weighted MRI. TMTCP-based assessment of various HIFU applications was also demonstrated. Conclusions: We developed a novel MR-imageable and HIFU-compatible TMTCP to characterize HIFU heating without MRI or thermocouples. The HIFU-optimized TMTCP reports absolute temperatures and ablation zone geometry with high spatial resolution. Consequently, the TMTCP can be used to evaluate HIFU heating and may provide an in vitro tool for peak temperature assessment, and reduce preclinical in vivo requirements for clinical translation.