Seroepidemiology of hepatitis C virus infection in hemodialysis patients and the general population in Fukuoka and Okinawa, Japan
Seroepidemiology of hepatitis C virus infection in hemodialysis patients and the general population in Fukuoka and Okinawa, Japan
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日本福冈和冲绳血液透析患者和一般人群丙型肝炎病毒感染的血清流行病学
DOI：
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发表时间：
1994
影响因子：
6.3
通讯作者：
S. Kashiwagi
中科院分区：
文献类型：
--
作者：
J. Hayashi;E. Yoshimura;A. Nabeshima;Y. Kishihara;H. Ikematsu;M. Hirata;Yoshiaki Maedia;S. Kashiwagi
1992年，在日本福冈和冲绳的血液透析患者和普通人群中进行了一项血清流行病学研究，以确定丙型肝炎病毒（HCV）感染和HCV病毒血症的存在。使用的标志物是HCV抗体，通过第二代检测（抗HCV）和HCV RNA，通过聚合酶链反应测定。福冈市抗-HCV阳性率为3.3%（73/2237），显著高于冲绳市的0.4%（5/1295）（P<0.001）。福冈市血液透析患者抗-HCV阳性率为51.9%（161/310），显著高于冲绳市的9.1%（13/143）（P<0.001）。血液透析患者HCVRNA/抗-HCV阳性率（147/174，84.5%）显著高于普通人群（49/78，62.8%）（P<0.001）。在血液透析患者中消除HCV似乎是困难的，因为这些患者的免疫应答比一般人群低。在福冈，从1953年到1969年，用于输血的血液是由商业血库的有偿献血者提供的，但冲绳没有。这可以解释为什么HCV感染在福冈而不是在冲绳流行。福冈和冲绳血液透析患者中抗-HCV患病率之间的差异反映了日本这两个地区一般人群中患病率的差异。
In 1992, a seroepidemiologic study was carried out among hemodialysis patients and the general population in Fukuoka and Okinawa, Japan to determine the presence of hepatitis C virus (HCV) infection and HCV viremia. The markers used were antibody to HCV, determined by second-generation assay (anti-HCV), and HCV RNA, determined by the polymerase chain reaction. The prevalence of anti-HCV in Fukuoka was 3.3%, 73 per 2237 persons, significantly (P<0.001) higher than the 0.4%, 5 per 1295, in Okinawa. The prevalence of anti-HCV in hemodialysis patients in Fukuoka was 51.9% (161 of 310 patients), significantly (P<0.001) higher than the 9.1% (13 of 143 patients) in Okinawa. The ratio of HCV RNA-positive to anti-HCV-positive persons was significantly higher in hemodialysis patients (147/174, 84.5%) than in the general population (49/78, 62.8%) (P<0.001). Elimination of HCV among hemodialysis patients appears to be difficult, as such patients have lower immune responses than the general population. In Fukuoka, but not in Okinawa, blood used for transfusion was supplied by paid donors at commercial blood banks from 1953 to 1969. This may explain why HCV infection is endemic in Fukuoka and not in Okinawa. Differences between the prevalence of anti-HCV in the hemodialysis patients in Fukuoka and Okinawa reflect differences in the prevalence in the general population in these two areas of Japan.
DOI：
10.1056/nejm199408113310612
发表时间：
1994-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
B. Gürakan;O. Oran;S. Yiğit
通讯作者：
B. Gürakan;O. Oran;S. Yiğit
DOI：
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发表时间：
1990
期刊：
JAMA : the journal of the American Medical Association
影响因子：
--
作者：
Stevens,CE;Taylor,PE;Pindyck,J;Choo,QL;Bradley,DW;Kuo,G;Houghton,M
通讯作者：
Houghton,M