Inhibition of gamma delta T cell recognition by receptors for MHC class I molecules.
Inhibition of gamma delta T cell recognition by receptors for MHC class I molecules.
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MHC I 类分子受体抑制 γ δ T 细胞识别。
DOI：
10.4049/jimmunol.155.9.4139
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发表时间：
1995
影响因子：
4.4
通讯作者：
M. Takiguchi
中科院分区：
文献类型：
--
作者：
H. Nakajima;H. Tomiyama;M. Takiguchi
NK 细胞具有 MHC I 类分子的受体，可抑制针对靶细胞的细胞毒性。我们表明，γδCTL 的识别受到 MHC I 类分子受体的负调节。靶细胞上多态性 HLA I 类分子的表达抑制了 γ δ CTL 克隆对 C1R 细胞的细胞溶解作用，并通过用抗 HLA I 类单克隆抗体阻断来恢复，这表明存在 HLA I 类分子的抑制性受体。 γδT 细胞上 HLA I 类分子的受体是异质的。对各种 Ag 的免疫反应可能通过 T 细胞和 NK 细胞上的这些抑制性受体进行调节。
NK cells have receptors for MHC class I molecules that inhibit cytotoxicity against target cells. We show that recognition of gamma delta CTL is negatively regulated by receptors for MHC class I molecules. Cytolysis of C1R cells by gamma delta CTL clones was inhibited by the expression of polymorphic HLA class I molecules on target cells and was restored by blocking with anti-HLA class I mAb, suggesting the presence of inhibitory receptors for HLA class I molecules. The receptors for HLA class I molecules on gamma delta T cells were heterogenous. The immune responses to various Ags may be regulated via these inhibitory receptors on T cells and NK cells.