Effect of early menopause on bone mineral density and fractures
Effect of early menopause on bone mineral density and fractures
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DOI：
10.1097/gme.0b013e31804c793d
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发表时间：
2007-05-01
影响因子：
2.7
通讯作者：
Gallagher, J. Christopher
中科院分区：
文献类型：
--
作者：
Gallagher, J. Christopher
目的：回顾早期绝经对骨骼影响的数据。经历早期更年期的女性是否会在较早年龄时骨矿物质密度较低，并且骨质疏松性骨折的发生率是否较高？提前自然绝经的女性与卵巢切除术后提前绝经的女性相比，其骨质是否存在差异？结果：绝经发生得越早，以后的骨密度就越低。低骨密度与较高的骨折率相关，一些研究表明提前绝经、卵巢切除术和骨质疏松性骨折增加之间存在关系。结论：提前绝经是骨质疏松症的危险因素。提前绝经的女性应在绝经后 10 年内进行骨密度测试，以便及早诊断骨质减少或骨质疏松症，并开始适当的抗骨吸收治疗。
Objective: To review the data on the effect of early menopause on bone. Do women undergoing early menopause develop lower bone mineral density at an earlier age and do they have a higher incidence of osteoporotic fractures? Is there a difference on bone between women who undergo early natural menopause compared to women who have early menopause after oophorectomy?Results: The earlier in life that menopause occurs, the lower the bone density will be later in life. Low bone density is associated with a higher fracture rate, and several studies show a relationship between early menopause, oophorectomy, and an increase in osteoporotic fractures.Conclusions: Early menopause is a risk factor for osteoporosis. Women with an early menopause should have bone density testing performed within 10 years of menopause so that osteopenia or osteoporosis will be diagnosed early and appropriate antiresorptive therapy initiated.