A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury.
A mitochondria-targeted nitric oxide donor triggered by superoxide radical to alleviate myocardial ischemia/reperfusion injury.
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由超氧自由基触发的线粒体靶向一氧化氮供体，可减轻心肌缺血/再灌注损伤。
DOI：
10.1039/c8cc07304j
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Liu Yangping
中科院分区：
文献类型：
--
作者：
Hou Jingli;He Haiyan;Huang Saipeng;Qian Meng;Wang Jie;Tan Xiaoli;Han Guifang;Song Yuguang;Xu Zhelong;Liu Yangping
通过将二苯基膦基和三苯基膦基团并入diazeniumdiolate中，开发了一种新型的靶向超氧化物响应性一氧化氮供体，能够显著保护H9 c2细胞和离体大鼠心脏免受缺血/再灌注损伤。
A novel mitochondria-targeted superoxide-responsive nitric oxide donor was developed by incorporation of diphenylphosphinyl and triphenylphosphonium groups into diazeniumdiolate, enabling remarkable protection against ischemia/reperfusion injury in H9c2 cells and isolated rat hearts.