Endothelial dysfunction: the early predictor of atherosclerosis.
Endothelial dysfunction: the early predictor of atherosclerosis.
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DOI：
10.5830/cvja-2011-068
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发表时间：
2012-05
影响因子：
0.7
通讯作者：
Strijdom H
中科院分区：
文献类型：
--
作者：
Mudau M;Genis A;Lochner A;Strijdom H
自20世纪80年代发现一氧化氮（NO）实际上是难以捉摸的内皮源性舒张因子以来，已经证明NO不仅是主要的心血管信号分子，而且其生物利用度的变化在决定动脉粥样硬化是否会发展中至关重要。与心血管危险因素（如糖尿病）相关的持续高水平有害循环刺激引起内皮细胞的反应，这些反应依次出现，即内皮细胞活化和内皮功能障碍（艾德）。艾德，其特征是降低NO生物利用度，现在被许多人认为是动脉粥样硬化的早期可逆的前兆。艾德的发病机制是多因素的;然而，氧化应激似乎是随后在身体血管系统中血管活性、炎症、止血和氧化还原稳态丧失的常见潜在细胞机制。艾德作为与心血管危险因素相关的早期内皮细胞变化和缺血性心脏病发展之间的病理生理学联系的作用对基础科学家和临床医生都很重要。
Since the discovery in the 1980s that nitric oxide (NO) is in fact the elusive endothelium-derived relaxing factor, it has become evident that NO is not only a major cardiovascular signalling molecule, but that changes in its bioavailability are crucial in determining whether atherosclerosis will develop or not. Sustained high levels of harmful circulating stimuli associated with cardiovascular risk factors such as diabetes mellitus elicit responses in endothelial cells that appear sequentially, namely endothelial cell activation and endothelial dysfunction (ED). ED, characterised by reduced NO bioavailability, is now recognised by many as an early, reversible precursor of atherosclerosis. The pathogenesis of ED is multifactorial; however, oxidative stress appears to be the common underlying cellular mechanism in the ensuing loss of vaso-active, inflammatory, haemostatic and redox homeostasis in the body’s vascular system. The role of ED as a pathophysiological link between early endothelial cell changes associated with cardiovascular risk factors and the development of ischaemic heart disease is of importance to basic scientists and clinicians alike.
影响因子：
4.5
作者：
Javanmard SH;Nematbakhsh M;Sanei MH
通讯作者：
Sanei MH