Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Potential Therapeutic Strategy for Acute Kidney Injury.
Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Potential Therapeutic Strategy for Acute Kidney Injury.
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DOI：
10.3389/fimmu.2021.684496
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发表时间：
2021
影响因子：
7.3
通讯作者：
Luo Z
中科院分区：
文献类型：
--
作者：
Li JK;Yang C;Su Y;Luo JC;Luo MH;Huang DL;Tu GW;Luo Z
急性肾损伤（AKI）是住院患者中一种常见且可能危及生命的疾病，占所有住院患者的10%-15%，约占重症监护病房患者的50%。严重的、复发的和不受控制的AKI可能发展为慢性肾脏疾病或终末期肾脏疾病。因此，AKI需要更有效、更有针对性的治疗，而不仅仅是支持性治疗。间充质干细胞（MSCs）被认为是很有前途的细胞治疗细胞，因为它们易于收获，免疫原性低，并且能够在体外扩增。最近的研究表明，间充质干细胞的主要治疗作用是由间充质干细胞衍生的细胞外囊泡（MSC-EVs）介导的。此外，与间充质干细胞相比，间充质干细胞- ev具有免疫原性较低、易于储存、不发生肿瘤以及人工修饰的潜力。本文综述了MSCs和msc - ev在AKI中的治疗机制，并对如何提高msc - ev在AKI中的疗效进行了综述。我们还总结和分析了EVs治疗AKI的潜力和局限性，为未来的临床试验和MSC-EVs在AKI中的临床应用提供思路。
Acute kidney injury (AKI) is a common and potential life-threatening disease in patients admitted to hospital, affecting 10%–15% of all hospitalizations and around 50% of patients in the intensive care unit. Severe, recurrent, and uncontrolled AKI may progress to chronic kidney disease or end-stage renal disease. AKI thus requires more efficient, specific therapies, rather than just supportive therapy. Mesenchymal stem cells (MSCs) are considered to be promising cells for cellular therapy because of their ease of harvesting, low immunogenicity, and ability to expand in vitro. Recent research indicated that the main therapeutic effects of MSCs were mediated by MSC-derived extracellular vesicles (MSC-EVs). Furthermore, compared with MSCs, MSC-EVs have lower immunogenicity, easier storage, no tumorigenesis, and the potential to be artificially modified. We reviewed the therapeutic mechanism of MSCs and MSC-EVs in AKI, and considered recent research on how to improve the efficacy of MSC-EVs in AKI. We also summarized and analyzed the potential and limitations of EVs for the treatment of AKI to provide ideas for future clinical trials and the clinical application of MSC-EVs in AKI.
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影响因子：
17.1
作者：
Cao, Hongmei;Cheng, Yuanqiu;Wang, Yuebing
通讯作者：
Wang, Yuebing
影响因子：
2.2
作者：
Baek, Rikke;Sondergaard, Evo K. L.;Jorgensen, Malene M.
通讯作者：
Jorgensen, Malene M.
影响因子：
3.8
作者：
Abumaree, M. H.;Abomaray, F. M.;Kalionis, B.
通讯作者：
Kalionis, B.
影响因子：
4.3
作者：
Caldas HC;Lojudice FH;Dias C;Fernandes-Charpiot IMM;Baptista MASF;Kawasaki-Oyama RS;Sogayar MC;Takiya CM;Abbud-Filho M
通讯作者：
Abbud-Filho M
影响因子：
3.7
作者：
Bruno S;Grange C;Collino F;Deregibus MC;Cantaluppi V;Biancone L;Tetta C;Camussi G
通讯作者：
Camussi G