1H-nmr analysis of herbimycins and dihydro-herbimycins.
1H-nmr analysis of herbimycins and dihydro-herbimycins.
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DOI：
10.1021/np50060a018
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发表时间：
1988-11
影响因子：
5.1
通讯作者：
L. Lin;G. Blaskó;G. Cordell
中科院分区：
文献类型：
--
作者：
L. Lin;G. Blaskó;G. Cordell
从吸水链霉菌细胞培养液中分别获得了除草霉素A [1]和除草霉素C [3]及其二氢衍生物5和6，并完成了它们的1H-NMR归属。抗生素 1、3、5 和 6 对 P-388 和 KB 淋巴细胞白血病测试系统具有很强的细胞毒活性。
Herbimycin A [1] and herbimycin C [3] and their dihydro-derivatives 5 and 6, respectively, have been obtained from the cell broth of Streptomyces hygroscopicus, and the assignment of their 1H-nmr has been completed. Strong cytotoxic activity of antibiotics 1, 3, 5, and 6 against the P-388 and KB lymphocytic leukemia test systems has been demonstrated.