Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production.
Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production.
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DOI：
10.1176/ajp.153.2.200
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发表时间：
1996-02
期刊：
影响因子：
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通讯作者：
D. Yurgelun-Todd;Christine Waternaux;Bruce M. Cohen;S. Gruber;C. D. English;P. Renshaw
中科院分区：
文献类型：
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作者：
D. Yurgelun-Todd;Christine Waternaux;Bruce M. Cohen;S. Gruber;C. D. English;P. Renshaw
目的 本研究旨在测试使用功能性磁共振成像 (MRI) 来检查两个大脑区域响应言语任务的皮层激活变化的可行性。方法 12 名精神分裂症患者和 11 名对照受试者接受了额叶和颞叶的功能性 MRI 检查。通过使用在静息状态和刺激状态之间交替的任务激活范例，刺激序列被分为五个 30 秒的片段。使用梯度回波脉冲序列每 30 秒收集一次功能图像。结果在单词流利度任务中，精神分裂症受试者的左额叶激活明显少于对照受试者，而左颞叶激活明显较多。结论 这些初步数据表明，功能性 MRI 能够灵敏地检测比较受试者和精神分裂症患者在较高皮质功能期间的激活差异。这些发现与 PET 研究一致，PET 研究报告了精神分裂症患者在挑战范式期间左额叶激活减少。
OBJECTIVE This study was undertaken to test the feasibility of using functional magnetic resonance imaging (MRI) to examine changes in cortical activation in response to verbal tasks in two brain regions. METHOD Twelve schizophrenic patients and 11 comparison subjects underwent functional MRI of the frontal and temporal lobes. Stimulus sequences were divided into five 30-second segments by using a task-activation paradigm that alternated between resting and stimulated states. Functional images were collected every 30 seconds by using a gradient echo pulse sequence. RESULTS Schizophrenic subjects demonstrated significantly less left frontal activation and greater left temporal activation than comparison subjects during a word fluency task. CONCLUSIONS These preliminary data suggest that functional MRI has the sensitivity to detect differences in activation between comparison subjects and schizophrenic patients during higher cortical functions. These findings are in agreement with PET studies that reported reduced left frontal activation during challenge paradigms for the schizophrenic patients.