Iodine-mediated oxidative cyclization for one pot synthesis of new 8-hydroxyquinaldine derivatives containing a N-phenylpyrazole moiety as pesticidal agents
Iodine-mediated oxidative cyclization for one pot synthesis of new 8-hydroxyquinaldine derivatives containing a N-phenylpyrazole moiety as pesticidal agents
复制标题
碘介导的氧化环化一锅合成含有 N-苯基吡唑部分的新型 8-羟基喹哪啶衍生物作为杀虫剂
DOI：
10.1016/j.bmcl.2018.08.041
复制
发表时间：
2018
影响因子：
2.7
通讯作者：
Guo Yong
中科院分区：
文献类型：
--
作者：
Xu Ting;Wang Xiaoguang;Zhang Qian;Fan Jiangping;Liu Liu;Liu Mingzhu;Zhang Haojie;Li Jing;Guo Yong
为了探索和开发新型农药，我们合成了一系列新的含N-苯基吡唑结构的8-羟基喹哪啶衍生物，其结构经1HNMR，IR，ESI-MS和mp.同时，发展了一种有效的碘介导氧化环化反应一锅法合成含N-苯基吡唑结构的8-羟基喹哪啶衍生物的方法。生物活性测定结果表明，化合物8和9 f对粘虫Mythimna separataWalker和小菜蛾Plutella xylostellaLinnaeus均有较强的杀虫活性。并对构效关系进行了讨论。
In continuation of our research aimed at discovery and development of new pesticidal agents, a series of new 8-hydroxyquinaldine derivatives containing aN–phenylpyrazole moiety were prepared and their structures were characterized by1H NMR, IR, ESI-MS and mp. Meanwhile, an efficient way of using iodine-mediated oxidative cyclization for one pot synthesis of these 8-hydroxyquinaldine derivatives containing aN–phenylpyrazole moiety was developed. The bioassay showed that compounds8gand9fexhibited potent pesticidal activities against bothMythimna separataWalker andPlutella xylostellaLinnaeus. The structure–activity relationships were also discussed.