A fast and simple method to fabricate circular microchannels in polydimethylsiloxane (PDMS)
A fast and simple method to fabricate circular microchannels in polydimethylsiloxane (PDMS)
复制标题
DOI：
10.1039/c0lc00093k
复制
发表时间：
2011-01-01
期刊：
影响因子：
6.1
通讯作者：
Sun, Yu
中科院分区：
文献类型：
--
作者：
Abdelgawad, Mohamed;Wu, Chun;Sun, Yu
提出了一种在聚二甲基硅氧烷（PDMS）中制备圆形微通道的简单方法。通过在填充PDMS的微通道内引入加压气流，将液体PDMS涂层应用于矩形微通道的壁上，这些微通道使用标准的软光刻技术制造。液态PDMS的表面张力迫使涂层采取圆形横截面，该横截面通过烘烤装置以固化所述涂层来保存。直径范围从几微米到几百微米被实现。该方法在微通道网络和直通道网络中均能正常工作。系统地测试了不同的涂层条件。设计曲线的一个报告，以选择适当的涂层条件，以获得所需的直径。方形微通道和圆形微通道在捕获SiHa细胞（宫颈癌细胞系）中的性能比较。
A simple method to fabricate circular microchannels in polydimethylsiloxane (PDMS) is presented. A coating of liquid PDMS is applied on the walls of rectangular microchannels, fabricated using standard soft-lithography, by introducing a pressurized air stream inside the PDMS filled microchannels. Surface tension of the liquid PDMS forces the coating to take a circular cross-section which is preserved by baking the device to cure the coated layer. Diameters ranging from a few micrometres to a few hundreds of micrometres were achieved. The method was verified to work on microchannel networks as well as in straight channels. Different coating conditions were systematically tested. Design curves are reported for one to choose appropriate coating conditions for obtaining a desired diameter. A comparison between the performance of square and circular microchannels in trapping SiHa cells (cervical cancer cell line) is shown.