PARASITIC HELMINTH INFECTION AND COGNITIVE FUNCTION IN SCHOOL-CHILDREN
PARASITIC HELMINTH INFECTION AND COGNITIVE FUNCTION IN SCHOOL-CHILDREN
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DOI：
10.1098/rspb.1992.0011
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发表时间：
1992-02-22
影响因子：
4.7
通讯作者：
BUNDY, DAP
中科院分区：
文献类型：
--
作者：
NOKES, C;GRANTHAMMCGREGOR, SM;BUNDY, DAP
本研究采用双盲安慰剂对照方案，调查了牙买加159名学龄儿童（9-12岁）中至高程度的毛滴虫感染对认知功能的影响。采用前向逐步多元线性回归对结果进行评价。去除蠕虫导致听觉短期记忆测试的显著改善（p < 0.017; p < 0.013），以及扫描和检索长期记忆（p < 0.001）。治疗9周后，接受治疗的儿童和未感染的对照组在这三项认知功能测试中不再有显著差异。结论：鞭虫感染对某些认知功能有不良影响，可通过治疗逆转。
The study examines the effect of moderate to high worm burdens of Trichuris trichiura infection on the cognitive functions of 159 school children (age 9-12 years) in jamaica, using a double-blind placebo-controlled protocol. Results were evaluated by using a forward-stepwise multiple linear regression. Removal of worms led to a significant improvement in tests of auditory short-term memory (p < 0.017; p < 0.013), and scanning and retrieval of long-term memory (p < 0.001). Nine weeks after treatment, there were no longer significant differences between the treated children and an uninfected Control group in these three tests of cognitive function. It is concluded that whipworm infection has an adverse effect on certain cognitive functions which is reversible by therapy.