Synergistic effects of unilateral immunolesions of the cholinergic projections from the basal forebrain and contralateral ablations of the inferotemporal cortex and hippocampus in monkeys
Synergistic effects of unilateral immunolesions of the cholinergic projections from the basal forebrain and contralateral ablations of the inferotemporal cortex and hippocampus in monkeys
复制标题
DOI：
10.1016/s0306-4522(00)00131-7
复制
发表时间：
2000-01-01
期刊：
影响因子：
3.3
通讯作者：
Ridley, RM
中科院分区：
文献类型：
--
作者：
Barefoot, HC;Baker, HF;Ridley, RM
猴，单侧免疫毒性病变的基底核的Meynert去除胆碱能神经支配的同侧新皮层，和消融对侧下颞叶新皮层，受损保留的视觉辨别力手术前学习和收购新的歧视。这表明来自基底核的胆碱能投射支持其皮质靶区的功能。我们以前的研究表明，双侧基底核病变后的歧视性能的损害是短暂的，双侧病变的斜角带的Broca，消除胆碱能神经支配的海马，是没有影响这些任务。然而，双侧基底核加斜角带损伤或双侧颞下皮质消融导致的损伤是严重和持续的。双侧颞下区消融通过在皮质-皮质传递中产生不连续性而剥夺了海马的大部分视觉输入，而基底核病变可能仅仅阻止颞下区皮质中视觉衍生信息的修改，而不剥夺海马的视觉输入。在单侧基底核和颞下皮质交叉损伤的猴中，在基底核损伤的基础上增加斜角带损伤，对视觉辨别的保持产生损害，并持续获得损害。这证实了先前的发现，即基底核和斜角带协同作用，产生严重和永久性的损害。进一步增加兴奋性海马损伤与颞下皮层消融的半球并没有增加学习障碍，这支持的建议，颞下皮层消融剥夺了海马的视觉输入。总之，这些实验表明，胆碱能投射从基底核和斜角带参与颞叶的学习和记忆功能。(C)2000 IBRO。由爱思唯尔科技有限公司出版。保留所有权利。
Monkeys, with unilateral immunotoxic lesions of the basal nucleus of Meynert that remove cholinergic innervation of the ipsilesional neocortex, and ablations of the contralateral inferotemporal neocortex, were impaired on retention of visual discriminations learnt before surgery and on acquisition of new discriminations. This demonstrates that the cholinergic projection from the basal nucleus supports the functions of its cortical target area. Our previous studies have shown that the impairment on discrimination performance following bilateral lesions of the basal nucleus is transient and that bilateral lesions of the diagonal band of Broca, that remove cholinergic innervation of the hippocampus, are without effect on these tasks. However, the impairment resulting from bilateral lesions of the basal nucleus plus the diagonal band, or from bilateral inferotemporal cortex ablations, is severe and persistent. Bilateral inferotemporal ablations deprive the hippocampus of much of its visual input by producing a discontinuity in cortico-cortical transmission, whereas basal nucleus lesions may merely prevent the modification of visually-derived information in the inferotemporal cortex without depriving the hippocampus of visual input. In the monkeys with crossed unilateral basal nucleus plus inferotemporal cortex lesions, the addition of a diagonal band lesion to the basal nucleus lesion produced an impairment on retention of visual discriminations and sustained the acquisition impairment. This confirms the previous finding that the basal nucleus and diagonal band act synergistically in producing a severe and permanent impairment. Further addition of an excitotoxic hippocampal lesion to the hemisphere with the inferotemporal cortex ablation did not add to the learning impairment, This supports the suggestion that the inferotemporal cortex ablation has deprived the hippocampus of its visual input.Overall, these experiments demonstrate that the cholinergic projections from the basal nucleus and diagonal band participate in the learning and memory functions of the temporal lobes. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.