Long-Term Results of Phase II Study of High Dose Photon/Proton Radiotherapy in the Management of Spine Chordomas, Chondrosarcomas, and Other Sarcomas
Long-Term Results of Phase II Study of High Dose Photon/Proton Radiotherapy in the Management of Spine Chordomas, Chondrosarcomas, and Other Sarcomas
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DOI：
10.1002/jso.23617
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发表时间：
2014-08-01
影响因子：
2.5
通讯作者：
Hornicek, Francis J.
中科院分区：
文献类型：
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作者：
Delaney, Thomas F.;Liebsch, Norbert J.;Hornicek, Francis J.
背景：脊柱肉瘤手术切缘阴性的情况很少见，因此可以推荐辅助放射治疗(RT)，但肿瘤剂量可能受到脊髓、神经和内脏耐受性的限制。方法：结合高剂量放射治疗的前瞻性II期临床试验。符合条件的患者有原发或局部复发的胸椎、腰椎和/或骶椎/脊柱旁脊索瘤或肉瘤。结果：50例患者(脊索瘤29例，软骨肉瘤14例，其他7例)接受了大体切除(n=25)或次全切除(n=12)或活检(n=13)。RT剂量为
Background: Negative surgical margins are uncommon for spine sarcomas; hence, adjuvant radiotherapy (RT) may be recommended but tumor dose may be constrained by spinal cord, nerve, and viscera tolerance.Methods: Prospective Phase II clinical trial incorporating high dose RT. Eligible patients had primary or locally recurrent thoracic, lumbar, and/or sacral spine/paraspinal chordomas or sarcomas. Treatment included pre- and/or post-operative photon/proton RT +/- radical resection.Results: Fifty patients (29 chordoma, 14 chondrosarcoma, 7 other) underwent gross total (n = 25) or subtotal (n = 12) resection or biopsy (n = 13). RT dose was