RELATIONSHIP BETWEEN EGF-R, C-ERBB-2 PROTEIN EXPRESSION AND KI67 IMMUNOSTAINING IN BREAST-CANCER AND HORMONE SENSITIVITY
RELATIONSHIP BETWEEN EGF-R, C-ERBB-2 PROTEIN EXPRESSION AND KI67 IMMUNOSTAINING IN BREAST-CANCER AND HORMONE SENSITIVITY
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DOI：
10.1016/s0959-8049(05)80215-1
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发表时间：
1993-01-01
影响因子：
8.4
通讯作者：
BLAMEY, RW
中科院分区：
文献类型：
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作者：
NICHOLSON, RI;MCCLELLAND, RA;BLAMEY, RW
表皮生长因子受体（EGF-R），c-erbB-2蛋白产物和Ki 67的表达已被评估在105个乳腺癌已知的内分泌治疗的反应，使用免疫组化。在62例肿瘤中观察到EGF-R染色，并与细胞增殖率升高（% Ki 67阳性细胞）和激素敏感性丧失显著相关。相反，c-erbB-2表达与细胞增殖率无关，与激素不敏感性的相关性较低。根据c-erbB-2测量结果对EGF-R数据进行细分，揭示了c-erbB-2免疫染色与中度EGF-R阳性肿瘤患者预后恶化和激素不敏感之间的相关性。c-erbB-2免疫染色在高度EGF-R阳性肿瘤并没有进一步有助于这些患者已经很差的预后。这些数据证实了EGF-R测量在乳腺癌中的预后重要性，并可能推断这种蛋白质和c-erbB-2蛋白产物在乳腺肿瘤亚组的异常生长中的功能相互作用。
The expression of the epidermal growth factor receptor (EGF-R), c-erbB-2 protein product and Ki67 have been evaluated in 105 breast cancers of known responsiveness to endocrine therapy using immunohistochemistry. EGF-R staining was observed in 62 of the tumours and was significantly associated with elevated rates of cell proliferation (%Ki67 positive cells) and loss of hormone sensitivity. In contrast, c-erbB-2 expression was not correlated with cell proliferation rates and was less strongly related to hormone insensitivity. Subdivision of the EGF-R data according to c-erbB-2 measurements revealed an association between c-erbB-2 immunostaining and worsened patient outlook and hormone insensitivity in moderately EGF-R-positive tumours. c-erbB-2 immunostaining in highly EGF-R-positive tumours did not further contribute to the already poor prognosis of these patients. These data confirm the prognostic importance of EGF-R measurements in breast cancer and may infer a functional interaction between this protein and the c-erbB-2 protein product in the aberrant growth of a subset of breast tumours.