Improved prognosis for patients with mediastinal lymphoblastic lymphoma.
Improved prognosis for patients with mediastinal lymphoblastic lymphoma.
复制标题
改善纵隔淋巴母细胞淋巴瘤患者的预后。
DOI：
10.1182/blood.v53.4.687.bloodjournal534687
复制
发表时间：
1979
期刊：
影响因子：
20.3
通讯作者：
D. Nathan
中科院分区：
文献类型：
--
作者：
H. Weinstein;Z. B. Vance;N. Jaffe;D. Buell;J. Cassady;D. Nathan
弥漫性淋巴母细胞性淋巴瘤(包括卷曲淋巴细胞性淋巴瘤)合并纵隔受累的患者可预见疾病进展到白血病阶段，在细胞学上与急性淋巴细胞白血病(ALL)难以区分。因此，我们对12例累及纵隔的弥漫性淋巴母细胞性淋巴瘤患者进行了治疗，该疗法对ALL有效。治疗包括阿霉素间歇联合化疗和预防性中枢神经系统治疗(头颈部放疗和鞘内甲氨蝶呤)。对于最初的呼吸窘迫或在诱导化疗后病情不完全消退的患者，给予纵隔放射治疗。11例患者完全缓解。中位随访时间为41个月，使用寿命表分析，86%的患者仍处于持续完全缓解状态。这项研究的结果证明了弥漫性淋巴母细胞淋巴瘤作为播散性淋巴系统恶性肿瘤治疗纵隔表现的有效性。
Patients with diffuse lymphoblastic lymphoma (which includes convoluted lymphocytic lymphoma) with mediastinal involvement have predictable progression of disease to a leukemic phase that is cytologically indistinguishable from acute lymphoblastic leukemia (ALL). Therefore we treated 12 patients with diffuse lymphoblastic lymphoma involving the mediastinum with therapy that is effective in ALL. Treatment consisted of intermittent combination chemotherapy with adriamycin and preventive central nervous system therapy (craniocervical irradiation and intrathecal methotrexate). Mediastinal irradiation was given either for initial respiratory distress or to patients who had incomplete regression of disease following induction chemotherapy. Eleven patients achieve complete remission. With a median follow-up of 41 mo, and using life table analysis, 86% of these patients have remained in continuous complete remission. The results of this study demonstrate the efficacy of treating diffuse lymphoblastic lymphoma with mediastinal presentation as a disseminated lymphoid malignancy.