Impaired virtual space-tilting perception in Parkinson's disease with Pisa syndrome
Impaired virtual space-tilting perception in Parkinson's disease with Pisa syndrome
复制标题
帕金森病合并比萨综合征的虚拟空间倾斜知觉受损
DOI：
10.1016/j.parkreldis.2022.09.002
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Hattori Nobutaka
中科院分区：
文献类型：
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作者：
Sasaki Fuyuko;Oyama Genko;Hirozane Yoshihiko;Yamashita Ryo;Sekimoto Satoko;Hattori Nobutaka
前言Pisa综合征在帕金森病(PD)中的发病机制尚不清楚。方法16例Pisa综合征患者、16例年龄匹配的非Pisa综合征患者和16例年龄匹配的正常对照。他们观察到虚拟房间从不同的8个不同方向逐渐倾斜，这些方向是在试验中随机进行的。评估了75%辨别阈值角度和每个方向的平均倾斜辨别角度。使用Kinect测量受试者的躯干侧方偏差。采用简易精神状态检查(MMSE)、日文版蒙特利尔认知评估(MoCA-J)、额头测验(FAB)和Stroop测试中的颜色词干扰任务对患者的神经心理状态进行评估。用Benton直线方位判断(BJLOT)评定视觉空间能力，用主观垂直视觉(SVV)评定前庭功能。结果Pisa综合征组在倾斜辨别角上的75%辨别阈值在各个方向上均高于无Pisa综合征组和对照组。前右、右、后三组之间存在显著差异。与非Pisa综合征患者相比，Pisa综合征患者的SVV表现更差。结论本研究结果支持Pisa综合征患者存在视觉空间障碍和/或注意障碍的假说。
IntroductionThe mechanism of Pisa syndrome in Parkinson's disease (PD) is unclear. We aimed to analyze the spatial perception of patients with PD with Pisa syndrome using virtual reality.MethodsIn total, 16 patients with Pisa syndrome, 16 age-matched patients without Pisa syndrome, and 16 age-matched controls were included. They viewed the virtual room gradually tilting from different 8 directions randomized across trials. The 75% discrimination threshold angle and the mean tilting discrimination angle for each direction were evaluated. Participants' lateral trunk deviation was measured using Kinect. Neuropsychological status was evaluated, using the Mini-Mental Status Examination (MMSE), the Japanese version of the Montreal-Cognitive Assessment (MoCA-J), Frontal Assessment Battery (FAB), and the color-word interference task of the Stroop test. Visuospatial abilities were assessed using Benton Judgement of Line Orientation (BJLOT), and vestibular function was evaluated using Subjective Visual Vertical (SVV).ResultsThe 75% discrimination threshold in the tilting discrimination angle was larger in all directions for those in the Pisa syndrome group compared to patients in the without Pisa syndrome group and those in the control group. There were significant differences between the three groups for Front-Right, Right, and Back. Patients with Pisa syndrome showed a significantly worse performance in these tests compared with controls and tended to have worse SVV performance compared with patients without Pisa syndrome.ConclusionThe present findings support the hypothesis of visuo-spatial disability and/or attentional impairment in patients with Pisa syndrome.