The metabolic syndrome and Alzheimer disease
The metabolic syndrome and Alzheimer disease
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DOI：
10.1001/archneur.64.1.93
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发表时间：
2007-01-01
影响因子：
--
通讯作者：
Wilcock, Gordon
中科院分区：
文献类型：
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作者：
Razay, George;Vreugdenhil, Anthea;Wilcock, Gordon
背景：代谢综合征是心血管疾病的危险因素，与阿尔茨海默病有关。目的：探讨代谢综合征与阿尔茨海默病之间的关系。设计、设置和参与者：对来自澳大利亚朗塞斯顿和英国布里斯托记忆障碍诊所的50例确诊为可能阿尔茨海默病的连续患者和75例认知正常对照进行病例对照研究。由国家胆固醇教育计划成人治疗小组III定义的代谢综合征的比值比。结果：与对照组相比，阿尔茨海默病患者的平均腰围明显更大，甘油三酯和葡萄糖的平均血浆浓度更高，高密度脂蛋白胆固醇的平均血浆浓度更低，但他们的平均收缩压更低。代谢综合征与阿尔茨海默病相关（比值比，3.2; 95%可信区间，1.2-8.4; P= 0.02），当排除高血压成分时，这种相关性得到加强（比值比，7.0; 95%可信区间，2.7-18.3; P = 0.02）。
Background: The metabolic syndrome is a risk factor for cardiovascular diseases, which have been linked to Alzheimer disease. However, a link between Alzheimer disease and the metabolic syndrome has not yet been established.Objective: To investigate the relationship between the metabolic syndrome and Alzheimer disease.Design, Setting, and Participants: Case-control study of 50 consecutive patients diagnosed with probable Alzheimer disease from the Memory Disorders Clinics, Launceston, Australia, and Bristol, England, and 75 cognitively normal controls.Main Outcome Measures: The odds ratio of the metabolic syndrome as defined by the National Cholesterol Education Program Adult Treatment Panel III.Results: Compared with controls, patients with Alzheimer disease had a significantly larger mean waist circumference, higher mean plasma concentrations of triglycerides and glucose, and a lower mean plasma concentration of high-density lipoprotein cholesterol, but they had lower mean systolic blood pressure. The metabolic syndrome was associated with Alzheimer disease (odds ratio, 3.2; 95% confidence interval, 1.2-8.4; P=.02), and this association was strengthened when the hypertension component was excluded (odds ratio, 7.0; 95% confidence interval, 2.7-18.3; P