A link between copper and dental caries in human teeth identified by X-ray fluorescence elemental mapping
A link between copper and dental caries in human teeth identified by X-ray fluorescence elemental mapping
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DOI：
10.1007/s00775-007-0321-z
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发表时间：
2008-02-01
影响因子：
3
通讯作者：
Lay, Peter A.
中科院分区：
文献类型：
--
作者：
Harris, Hugh H.;Vogt, Stefan;Lay, Peter A.
定量X射线荧光成像的部分人类牙齿显示，增加浓度的铜和锌的牙本质龋区相比，未受影响的部分的牙齿。更高分辨率的图像提供了强有力的证据，证明铜主要在牙本质小管中运输和定位。虽然在这些区域中发现了类似水平的锌，并集中在小管中，但锌在羟基磷灰石中也更明显，与背景（正常）区域中的水平相比，锌水平的增加小于铜。这些结果表明铜和锌在龋齿的形成和发展中的作用，并提出了一个潜在的治疗干预点。
Quantitative X-ray fluorescence imaging of sections of human teeth revealed an increased concentration of copper and zinc in carious regions of dentine compared with unaffected portions of the tooth. Higher-resolution images provided strong evidence that the copper was transported and localized mainly in the dentinal tubules. While similar levels of zinc were found in these areas and concentrated in the tubules, zinc was also more evident in the hydroxyapatite, and the increase in zinc levels compared with the levels in background (normal) areas was less than that for copper. These results suggest a role for copper and zinc in the formation and progression of dental caries and present a potential point of intervention for treatment.